de Kozak Yvonne, Verwaerde Claudie
INSERM U450, Paris, France.
Int Rev Immunol. 2002 Mar-Jun;21(2-3):231-53. doi: 10.1080/08830180212060.
A better understanding of the basic mechanisms of uveitis and of the role of cytokines in experimental ocular inflammation autoimmune diseases should allow us to define new approaches for therapy. Modulation of the cytokine network by either blocking cytokine activity or administration of regulatory Th2 cytokines has shown its efficacy in several experimental autoimmune diseases including uveitis. However, cytokines present pleiotropic activities and thus may exert different effects depending on the autoimmune diseases, making interventions on their production complex. Anti-cytokine therapy or a combination of anti-cytokine drugs, antibodies, and cytokine gene therapy to synergize the therapeutical effects of other treatments appear to be of interest. Improvements in drug delivery and in biotechnology will also allow us to elaborate new and safe immunomodulatory strategies.
更好地理解葡萄膜炎的基本机制以及细胞因子在实验性眼部炎症自身免疫性疾病中的作用，将有助于我们确定新的治疗方法。通过阻断细胞因子活性或给予调节性Th2细胞因子来调节细胞因子网络，已在包括葡萄膜炎在内的几种实验性自身免疫性疾病中显示出其疗效。然而，细胞因子具有多效性，因此可能根据自身免疫性疾病产生不同的作用，这使得对其产生进行干预变得复杂。抗细胞因子疗法或抗细胞因子药物、抗体和细胞因子基因疗法的联合使用，以增强其他治疗的疗效，似乎是有意义的。药物递送和生物技术的改进也将使我们能够制定新的、安全的免疫调节策略。
