Weckmann A L, Alcocer-Varela J
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico City, Mexico.
Semin Arthritis Rheum. 1996 Oct;26(2):539-57. doi: 10.1016/s0049-0172(96)80042-4.
The cytokine network participates in the modulation of the immune system. Furthermore, the formation of the cytokine-receptor complex, as well as the transcription, translation, secretion, or degradation of cytokines interfere with the functions of cytokines. Cytokine inhibitors include antagonists, soluble receptors, cytokine-binding proteins, and cytokines that block other cytokines. In autoimmune diseases, an abnormal production of proinflammatory cytokines, or a reduced inhibition of their actions, may lead to an imbalance. The main cytokine inhibitors include interleukin-1 receptor antagonist (IL-1ra), soluble IL-1 receptor (sIL-1R), soluble TNF-alpha receptors (soluble TNF-Rs), and certain cytokines, such as IL-4, TGF beta, and IL-10. The combination of cytokine inhibitors is a potential therapeutic approach in the treatment of immunoinflammatory diseases. The nonspecific effects of immunosuppressive drugs are improved by using inhibitors with more specific actions on the functions of proinflammatory cytokines.
细胞因子网络参与免疫系统的调节。此外，细胞因子 - 受体复合物的形成以及细胞因子的转录、翻译、分泌或降解都会干扰细胞因子的功能。细胞因子抑制剂包括拮抗剂、可溶性受体、细胞因子结合蛋白以及阻断其他细胞因子的细胞因子。在自身免疫性疾病中，促炎细胞因子的异常产生或其作用抑制的降低可能导致失衡。主要的细胞因子抑制剂包括白细胞介素 -1 受体拮抗剂（IL -1ra）、可溶性 IL -1 受体（sIL -1R）、可溶性肿瘤坏死因子 -α 受体（可溶性 TNF -Rs）以及某些细胞因子，如 IL -4、转化生长因子 β（TGF β）和 IL -10。细胞因子抑制剂的联合使用是治疗免疫炎症性疾病的一种潜在治疗方法。通过使用对促炎细胞因子功能具有更特异性作用的抑制剂，可以改善免疫抑制药物的非特异性作用。
