Ghadimi B M, Langer C, Becker H
Klinik und Poliklinik für Allgemeinchirurgie, Universitätsklinikum Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen.
Chirurg. 2002 Aug;73(8):833-7. doi: 10.1007/s00104-002-0488-3.
The implantation of meshes to correct inguinal as well as incisional hernias is widely used in the U.S.A. and Western Europe. The short and long term results of meshes are convincing concerning complications, recurrence rate and patient's comfort. On the other hand side some scientific groups discuss the possibility of malignant tumor development due to implanted meshes. In fact, experimental models exist which demonstrate that soft tissue sarcomas can be induced in mice and rats by implanting artificial materials such as synthetics or metal. Beside millions of hernia repairs using meshes worldwide no patient has been reported with a soft tissue tumor until today. The analyses of molecular markers of proliferation, of apoptosis as well as the modulation of heat shock proteins seem not to prove the carcinogenic potential of meshes. In conclusion, there are no data so far indicating a real risk for humans to develop malignant tumors due to implanted meshes. Therefore we further propagate the implantation of meshes in hernia repair in adult patients.
在美国和西欧，植入补片来矫正腹股沟疝和切口疝被广泛应用。补片在短期和长期的效果在并发症、复发率和患者舒适度方面令人信服。另一方面，一些科研团队讨论了植入补片导致恶性肿瘤发生的可能性。事实上，存在实验模型表明，通过植入合成材料或金属等人工材料，可以在小鼠和大鼠中诱发软组织肉瘤。尽管全球有数以百万计使用补片的疝修补手术，但迄今为止尚无患者被报道发生软组织肿瘤。对增殖、凋亡的分子标志物以及热休克蛋白调节的分析似乎并未证实补片具有致癌潜力。总之，目前尚无数据表明植入补片会给人类带来患恶性肿瘤的实际风险。因此，我们继续提倡在成年患者的疝修补术中植入补片。
