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DNA microarray analysis of the expression profile of Escherichia coli in response to treatment with 4,5-dihydroxy-2-cyclopenten-1-one.大肠杆菌对4,5-二羟基-2-环戊烯-1-酮处理反应的表达谱的DNA微阵列分析
J Bacteriol. 2002 Dec;184(23):6725-9. doi: 10.1128/JB.184.23.6725-6729.2002.
2
SigmaS-dependent gene expression at the onset of stationary phase in Escherichia coli: function of sigmaS-dependent genes and identification of their promoter sequences.大肠杆菌稳定期开始时依赖σS的基因表达：依赖σS的基因功能及其启动子序列的鉴定
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本文引用的文献

1
The product of the cysK gene of Bacillus stearothermophilus V mediates potassium tellurite resistance in Escherichia coli.嗜热脂肪芽孢杆菌V的cysK基因产物介导大肠杆菌对亚碲酸钾的抗性。
Curr Microbiol. 2001 Dec;43(6):418-23. doi: 10.1007/s002840010331.
2
Singlet molecular oxygen triggers the soxRS regulon of Escherichia coli.单线态分子氧触发大肠杆菌的soxRS调节子。
Biol Chem. 2001 Jul;382(7):1071-5. doi: 10.1515/BC.2001.134.
3
Antibacterial activity of 4,5-dihydroxy-2-cyclopentan-1-one (DHCP) and cloning of a gene conferring DHCP resistance in Escherichia coli.4,5-二羟基-2-环戊酮（DHCP）的抗菌活性及大肠杆菌中赋予DHCP抗性的基因克隆
J Mol Microbiol Biotechnol. 2001 Jul;3(3):461-5.
4
Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal media.大肠杆菌CreBC是一种基因表达的全局调节因子，可响应在基本培养基中的生长。
J Biol Chem. 2001 Jul 20;276(29):26955-61. doi: 10.1074/jbc.M011186200. Epub 2001 May 11.
5
Role of CspC and CspE in regulation of expression of RpoS and UspA, the stress response proteins in Escherichia coli.CspC和CspE在大肠杆菌中对压力反应蛋白RpoS和UspA表达调控中的作用。
J Bacteriol. 2001 Feb;183(4):1205-14. doi: 10.1128/JB.183.4.1205-1214.2001.
6
The role of cysteine residues in tellurite resistance mediated by the TehAB determinant.半胱氨酸残基在由TehAB决定簇介导的亚碲酸盐抗性中的作用。
Biochem Biophys Res Commun. 2000 Oct 22;277(2):394-400. doi: 10.1006/bbrc.2000.3686.
7
Neisseria gonorrhoeae bacterioferritin: structural heterogeneity, involvement in iron storage and protection against oxidative stress.淋病奈瑟菌细菌铁蛋白：结构异质性、参与铁储存及抵御氧化应激
Microbiology (Reading). 1999 Oct;145 ( Pt 10):2967-75. doi: 10.1099/00221287-145-10-2967.
8
Binding of tellurium to hepatocellular selenoproteins during incubation with inorganic tellurite: consequences for the activity of selenium-dependent glutathione peroxidase.在与无机亚碲酸盐孵育期间碲与肝细胞硒蛋白的结合：对硒依赖性谷胱甘肽过氧化物酶活性的影响。
Int J Biochem Cell Biol. 1999 Feb;31(2):291-301. doi: 10.1016/s1357-2725(98)00113-7.
9
Protection of DNA during oxidative stress by the nonspecific DNA-binding protein Dps.非特异性DNA结合蛋白Dps在氧化应激期间对DNA的保护作用。
J Bacteriol. 1997 Aug;179(16):5188-94. doi: 10.1128/jb.179.16.5188-5194.1997.
10
Expression of Escherichia coli TehA gives resistance to antiseptics and disinfectants similar to that conferred by multidrug resistance efflux pumps.大肠杆菌TehA的表达赋予了对防腐剂和消毒剂的抗性，这与多药耐药性外排泵所赋予的抗性相似。
Antimicrob Agents Chemother. 1997 Feb;41(2):440-4. doi: 10.1128/AAC.41.2.440.

大肠杆菌对4,5-二羟基-2-环戊烯-1-酮处理反应的表达谱的DNA微阵列分析

DNA microarray analysis of the expression profile of Escherichia coli in response to treatment with 4,5-dihydroxy-2-cyclopenten-1-one.

作者信息

Phadtare Sangita, Kato Ikunoshin, Inouye Masayori

机构信息

Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

出版信息

J Bacteriol. 2002 Dec;184(23):6725-9. doi: 10.1128/JB.184.23.6725-6729.2002.

DOI:10.1128/JB.184.23.6725-6729.2002
PMID:12426362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC135408/
Abstract

We carried out DNA microarray-based global transcript profiling of Escherichia coli in response to 4,5-dihydroxy-2-cyclopenten-1-one to explore the manifestation of its antibacterial activity. We show that it has widespread effects in E. coli affecting genes encoding proteins involved in cell metabolism and membrane synthesis and functions. Genes belonging to the regulon involved in synthesis of Cys are upregulated. In addition, rpoS and RpoS-regulated genes responding to various stresses and a number of genes responding to oxidative stress are upregulated.

摘要

我们利用基于DNA微阵列的技术对大肠杆菌进行了全转录组分析，以探究其对4,5 - 二羟基 - 2 - 环戊烯 - 1 - 酮的抗菌活性表现。我们发现它对大肠杆菌具有广泛影响，涉及影响编码参与细胞代谢、膜合成及功能的蛋白质的基因。属于参与半胱氨酸合成的调节子的基因上调。此外，对各种应激作出反应的rpoS及RpoS调节基因以及一些对氧化应激作出反应的基因也上调。