Thai Thao P, Houghton Pamela E, Campbell Karen E, Woodbury M Gail
School of Physical Therapy, University of Western Ontario, Elborn College, London, Ontario, N6G 1H, Canada.
Ostomy Wound Manage. 2002 Nov;48(11):52-60.
The prevalence of antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus is rapidly increasing in healthcare facilities and spreading to the community. Methicillin-resistant S. aureus colonize the skin and open wounds and can interfere with wound healing. Recent studies have shown that ultraviolet light C can kill antibiotic-resistant strains of bacteria such as methicillin-resistant S. aureus in both laboratory cultures and animal tissue. This clinical report describes the effects of ultraviolet light C on wound bioburden and closure in three people with chronic ulcers infected with methicillin-resistant S. aureus. In all three patients, ultraviolet light C treatment reduced wound bioburden and facilitated wound healing. Two patients had complete wound closure following 1 week of ultraviolet light C treatment. This case study suggests that ultraviolet light C is a promising adjunctive therapy for chronic wounds containing antibiotic-resistant bacteria such as methicillin-resistant S. aureus.
耐甲氧西林金黄色葡萄球菌等耐抗生素细菌在医疗机构中的流行率正在迅速上升，并蔓延至社区。耐甲氧西林金黄色葡萄球菌定植于皮肤和开放性伤口，会干扰伤口愈合。最近的研究表明，紫外线C在实验室培养和动物组织中均能杀死耐甲氧西林金黄色葡萄球菌等耐抗生素细菌菌株。本临床报告描述了紫外线C对3例感染耐甲氧西林金黄色葡萄球菌的慢性溃疡患者伤口生物负荷和愈合的影响。在所有3例患者中，紫外线C治疗均降低了伤口生物负荷并促进了伤口愈合。2例患者在接受1周紫外线C治疗后伤口完全闭合。本病例研究表明，紫外线C对于含有耐甲氧西林金黄色葡萄球菌等耐抗生素细菌的慢性伤口是一种有前景的辅助治疗方法。
