Stratz Thomas, Varga Boglarka, Müller Wolfgang
Hochrhein-Institut für Rehabilitationsforschung, Bergseestrasse 61, 79713 Bad Säckingen, Germany.
Rheumatol Int. 2002 Nov;22(6):219-21. doi: 10.1007/s00296-002-0233-8. Epub 2002 Sep 5.
A comparison between a local anesthetic drug and the 5-hydroxytryptamine 3 (5-HT3) receptor antagonist tropisetron in treating tendopathies or periarthropathies revealed that tropisetron has a longer effect on resting pain and pain on movement than the local anesthetic drug. The most likely explanation for this effect probably is a blocking of stimulated 5-HT3 receptors at the nociceptors in conjunction with an inhibited release of substance P and other neurokines because of this blockage. Further studies will have to show whether the action of tropisetron in tendopathies is as favorable as that of corticosteroids.
一项关于局部麻醉药物与5-羟色胺3（5-HT3）受体拮抗剂托烷司琼治疗肌腱病或关节周围疾病的比较显示，与局部麻醉药物相比，托烷司琼对静息痛和运动痛的作用持续时间更长。这种作用最可能的解释可能是，托烷司琼阻断了伤害感受器处受刺激的5-HT3受体，并因这种阻断抑制了P物质和其他神经激肽的释放。进一步的研究将必须表明托烷司琼在肌腱病中的作用是否与皮质类固醇一样有利。
