Sommer Claudia
Department of Neurology, University of Würzburg, Germany.
Mol Neurobiol. 2004 Oct;30(2):117-25. doi: 10.1385/MN:30:2:117.
The purpose of this article is to summarize recent findings on the role of serotonin in pain processing in the peripheral nervous system. Serotonin (5-hydroxtryptamine [5-HT]) is present in central and peripheral serotonergic neurons, it is released from platelets and mast cells after tissue injury, and it exerts algesic and analgesic effects depending on the site of action and the receptor subtype. After nerve injury, the 5-HT content in the lesioned nerve increases. 5-HT receptors of the 5-HT3 and 5-HT2A subtype are present on C-fibers. 5-HT, acting in combination with other inflammatory mediators, may ectopically excite and sensitize afferent nerve fibers, thus contributing to peripheral sensitization and hyperalgesia in inflammation and nerve injury.
本文旨在总结血清素在周围神经系统疼痛处理中作用的近期研究结果。血清素（5-羟色胺[5-HT]）存在于中枢和外周的血清素能神经元中，在组织损伤后从血小板和肥大细胞中释放出来，并且根据作用部位和受体亚型发挥致痛和镇痛作用。神经损伤后，损伤神经中的5-HT含量增加。5-HT3和5-HT2A亚型的5-HT受体存在于C纤维上。5-HT与其他炎症介质联合作用，可能会异位兴奋并致敏传入神经纤维，从而导致炎症和神经损伤中的外周敏化和痛觉过敏。
