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[Phalloidin antagonists/3rd communication: effects of antamanide derivatives in isolated perfused rat livers (author's transl)].

作者信息

Frimmer M, Petzinger E

出版信息

Arzneimittelforschung. 1975 Sep;25(9):1423-6.

PMID:1242667
Abstract

The protective effects of antamanide, O-carboxy-methyl-Tyr5-antamanide and of Tyr6-antamanide-monosulfate against phalloidin were tested in perfused rat livers. None of the applied doses was able to inhibit swelling and potassium loss of poisoned livers completely. In the perfused liver antamanide preferentially inhibited swelling but not potassium loss. O-Carboxymethyl-Tyr5-antamanide protected isolated hepatocytes against phalloidin. The different effects of antamanide derivatives in perfused livers and in vivo are discussed.

摘要

相似文献

1
[Phalloidin antagonists/3rd communication: effects of antamanide derivatives in isolated perfused rat livers (author's transl)].
Arzneimittelforschung. 1975 Sep;25(9):1423-6.
2
[Phalloidine antagonists. 1. Effects of silybine derivatives on isolated perfused rat liver].[鬼笔环肽拮抗剂。1. 水飞蓟宾衍生物对离体灌注大鼠肝脏的影响]
Arzneimittelforschung. 1975 Mar;25(3):394-6.
3
[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes].[鬼笔环肽拮抗剂。2. 二氢杨梅素对离体肝细胞鬼笔环肽中毒的保护作用]
Arzneimittelforschung. 1975 Apr;25(4):571-6.
4
[Phalloidin antagonists 4th communication: Thioctic acid, SH-compounds, rifampicin, choleretics, dexamethasone, estradiol, unspecific inhibitors, and ineffective compounds (author's transl)].[鬼笔环肽拮抗剂的第四次通讯：硫辛酸、含巯基化合物、利福平、利胆剂、地塞米松、雌二醇、非特异性抑制剂及无效化合物（作者译）]
Arzneimittelforschung. 1975;25(12):1881-4.
5
Antamanide antagonizes the phalloidin-induced negative inotropic effect and blocks voltage dependently the fast outward K+ current in voltage-clamped frog muscle fibres.鹅膏蕈氨酸拮抗鬼笔环肽诱导的负性肌力作用，并在电压钳制的青蛙肌肉纤维中电压依赖性地阻断快速外向钾电流。
Eur J Pharmacol. 1987 Jun 12;138(1):21-7. doi: 10.1016/0014-2999(87)90332-3.
6
Molecular aspects of cytoprotection by modified somatostatins.修饰生长抑素的细胞保护作用的分子机制
Klin Wochenschr. 1986;64 Suppl 7:87-9.
7
Prevention of phalloidin-induced lesions on isolated rat hepatocytes by novel synthetic analogues of somatostatin.生长抑素新型合成类似物对鬼笔环肽诱导的离体大鼠肝细胞损伤的预防作用
Klin Wochenschr. 1986;64 Suppl 7:79-86.
8
Differential effect of raised Mg2+ concentration of K+ ion movement and on swelling in the isolated perfused rat liver poisoned by phalloidin.升高的镁离子浓度对由鬼笔环肽中毒的离体灌注大鼠肝脏中钾离子移动及肿胀的差异效应。
Naunyn Schmiedebergs Arch Pharmacol. 1976 May;293(2):197-8. doi: 10.1007/BF00499229.
9
Anatamanide protects hepatocytes from phalloidin destruction.
Hoppe Seylers Z Physiol Chem. 1974 Sep;355(9):1162-3.
10
Antamanide antagonizes phalloidin-induced human lymphocyte aggregation and prevents leukaemic mice from death: a pilot study.鹅膏蕈氨酸拮抗剂拮抗鬼笔环肽诱导的人淋巴细胞聚集并防止白血病小鼠死亡：一项初步研究。
Acta Pharmacol Toxicol (Copenh). 1986 Sep;59(3):249-51. doi: 10.1111/j.1600-0773.1986.tb00162.x.

引用本文的文献

1
The role of plasma membranes in hepatotoxic effects.
Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S15-9. doi: 10.1007/BF00587764.
2
The role of bile acids in phalloidin poisoning.胆汁酸在鬼笔环肽中毒中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Dec;301(2):145-7. doi: 10.1007/BF00501430.
3
Trypsin protection of hepatocytes against phalloidin.
Naunyn Schmiedebergs Arch Pharmacol. 1977 Nov;300(2):163-71. doi: 10.1007/BF00505047.
4
Scanning electron microscopic studies on the cytolytic effect of phallolysin on isolated rat hepatocytes and AS-30 D hepatoma cells.
Naunyn Schmiedebergs Arch Pharmacol. 1976 Dec;295(3):211-3. doi: 10.1007/BF00505088.