胆汁酸在鬼笔环肽中毒中的作用。
The role of bile acids in phalloidin poisoning.
作者信息
Frimmer M, Petzinger E, Rufeger U, Veil L B
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1977 Dec;301(2):145-7. doi: 10.1007/BF00501430.
PMID:600327
Abstract
Glycocholate and other bile acids inhibit the response of isolated hepatocytes to phalloidin in a concentration dependent manner. It is suggested that the inhibition is due to a block of phalloidin uptake. This interaction might explain the high specificity of phalloidin for liver tissue.
摘要
甘胆酸和其他胆汁酸以浓度依赖性方式抑制分离的肝细胞对鬼笔环肽的反应。提示这种抑制作用是由于鬼笔环肽摄取受阻所致。这种相互作用可能解释了鬼笔环肽对肝组织的高特异性。
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