[On the method of injecting into the yolk-sac in teratological studies in rabbits (author's transl)].

A method is described by which the embryotoxic and teratogenic effects of substances can be examined through their application into the yolk-sac. On the ninth day of gestation rabbits (white New Zealand) were laparatomised and the uterus bicornis together with the blastoderms were treated in 3 different experiments. The results show that after application of physiological saline into the yolk-sac the high rate of malformations and resorptions are caused mainly by an avoidable venous obstruction and by postoperative inflammations and infections.