Dörner T, Odendahl M, Radbruch A
Med. Klinik m. S. Rheumatologie und Klin. Immunologie, Charité Berlin Schumannstr. 20/21 10098 Berlin, Germany.
Z Rheumatol. 2002 Aug;61(4):389-95. doi: 10.1007/s00393-002-0433-3.
A number of autoantibodies play a significant role in collagen vascular diseases and represent diagnostic markers of some of these entities. Despite increasing knowledge of these serological findings, data are limited about potential disturbances of precursor cells that finally lead to the autoantibody producing plasma cells. Recent evidence of disturbed B cell homeostasis indicates that the peripheral B cell compartments in systemic lupus erythematodes (SLE) and Sjögren's syndrome are characteristically different to normal. Although the identification of autoreactive B cells in peripheral blood is still subject of ongoing studies, the differences in B cell subsets add to the understanding of the immunopathogenesis of these diseases and may provide new diagnostic clues and therapeutical avenues of these entities.
多种自身抗体在胶原血管病中发挥重要作用，是其中一些疾病的诊断标志物。尽管对这些血清学发现的认识不断增加，但关于最终导致产生自身抗体的浆细胞的前体细胞潜在紊乱的数据仍然有限。最近关于B细胞内环境稳定紊乱的证据表明，系统性红斑狼疮（SLE）和干燥综合征的外周B细胞区室与正常情况有显著差异。虽然外周血中自身反应性B细胞的鉴定仍是正在进行的研究课题，但B细胞亚群的差异有助于理解这些疾病的免疫发病机制，并可能为这些疾病提供新的诊断线索和治疗途径。
