Sinden R E
Biological Sciences Department, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK.
Cell Microbiol. 2002 Nov;4(11):713-24. doi: 10.1046/j.1462-5822.2002.00229.x.
Our understanding of the intricate interactions between the malarial parasite and the mosquito vector is complicated both by the number and diversity of parasite and vector species, and by the experimental inaccessibility of phenomena under investigation. Steady developments in techniques to study the parasite in the mosquito have recently been augmented by methods to culture in their entirety the sporogonic stages of some parasite species. These, together with the new saturation technologies, and genetic transformation of both parasite and vector will permit penetrating studies into an exciting and largely unknown area of parasite-host interactions, an understanding of which must result in the development of new intervention strategies. This microreview highlights key areas of current basic molecular interest, and identifies numerous lacunae in our knowledge that must be filled if we are to make rational decisions for future control strategies. It will conclude by trying to explain why in the opinion of this reviewer understanding malaria-mosquito interactions may be critical to our future attempts to limit a disease of growing global importance.
疟原虫与蚊媒之间复杂的相互作用，因寄生虫和蚊媒物种的数量及多样性，以及所研究现象在实验上难以触及而变得复杂。近期，研究蚊体内寄生虫的技术不断取得稳步进展，同时一些寄生虫物种的孢子生殖阶段得以完全培养的方法也得到了补充。这些技术，再加上新的饱和技术以及寄生虫和蚊媒的基因改造，将使我们能够深入研究寄生虫与宿主相互作用这一令人兴奋但大多未知的领域，而对这一领域的理解必将催生新的干预策略。本微综述重点介绍了当前基础分子研究的关键领域，并指出了我们知识中的诸多空白，若要为未来的控制策略做出合理决策，这些空白必须填补。最后，本文将试图解释为何在作者看来，理解疟疾与蚊媒的相互作用对于我们未来控制这一全球重要性日益增加的疾病的努力可能至关重要。
