Frankel Paul
Department of Biostatistics, City of Hope National Medical Center, Duarte, CA 91010-3000, USA.
Cell Prolif. 2002 Dec;35(6):363-7. doi: 10.1046/j.1365-2184.2002.00247.x.
The ability of intercellular communication and the basement membrane to revert the phenotypic behaviour of malignant cells suggests that such cells can be tuned to behave more benignly. In addition, the large variation in cell doubling times observed in tumour cells poses the question of whether or not cell doubling times, and hence, patient survival, can be lengthened by therapeutic intervention. In both cases, the understanding may be enhanced by obtaining a parsimonious and tractable model of the cell cycle which behaves appropriately and suggests a philosophical framework for addressing these complex issues. We introduce a simple two-dimensional model based on averaging cyclin and maturation promotion factor over a fast oscillating subsystem that exhibits the basic features of cellular division, and discuss the ramifications of the model.
细胞间通讯以及基底膜使恶性细胞表型行为发生逆转的能力表明，此类细胞能够被调控从而表现得更为良性。此外，在肿瘤细胞中观察到的细胞倍增时间存在很大差异，这就提出了一个问题，即细胞倍增时间以及患者生存期是否能够通过治疗干预得以延长。在这两种情况下，通过获得一个简约且易于处理的细胞周期模型，该模型能够恰当表现并为解决这些复杂问题提供一个哲学框架，或许可以增进理解。我们基于在一个快速振荡子系统上对细胞周期蛋白和成熟促进因子进行平均，引入了一个简单的二维模型，该模型展现了细胞分裂的基本特征，并讨论了该模型的影响。
