细胞分裂周期建模：细胞周期蛋白依赖性激酶2（cdc2）与细胞周期蛋白的相互作用
Modeling the cell division cycle: cdc2 and cyclin interactions.
作者信息
Tyson J J
机构信息
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
出版信息
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7328-32. doi: 10.1073/pnas.88.16.7328.
Abstract
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
摘要
蛋白质cdc2和细胞周期蛋白形成一种异二聚体（成熟促进因子），它控制着细胞周期的主要事件。构建了一个关于cdc2和细胞周期蛋白相互作用的数学模型。对该模型的模拟和分析表明，控制系统可以以三种模式运行：作为具有高成熟促进因子活性的稳态、作为自发振荡器或作为可兴奋开关。我们将稳态与未受精卵中的中期停滞相关联，将自发振荡与早期胚胎中的快速分裂周期相关联，将可兴奋开关与非胚胎细胞典型的生长控制分裂周期相关联。
相似文献
1
Modeling the cell division cycle: cdc2 and cyclin interactions.细胞分裂周期建模：细胞周期蛋白依赖性激酶2（cdc2）与细胞周期蛋白的相互作用
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7328-32. doi: 10.1073/pnas.88.16.7328.
2
Mathematical models of the early embryonic cell cycle: the role of MPF activation and cyclin degradation.
J Math Biol. 1994;32(6):573-96. doi: 10.1007/BF00573462.
3
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.一种涉及细胞周期蛋白和cdc2激酶的有丝分裂振荡器的最小级联模型。
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9107-11. doi: 10.1073/pnas.88.20.9107.
4
From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?从Cdc2到Cdk1：细胞周期激酶何时与其周期蛋白伴侣结合？
J Cell Sci. 2002 Jun 15;115(Pt 12):2461-4. doi: 10.1242/jcs.115.12.2461.
5
[Control of cell division in eucaryotes].[真核生物中细胞分裂的控制]
Pathol Biol (Paris). 1993 Mar;41(3):260-7.
6
Protein kinase A regulates cell cycle progression of mouse fertilized eggs by means of MPF.蛋白激酶A通过成熟促进因子调控小鼠受精卵的细胞周期进程。
Dev Dyn. 2005 Jan;232(1):98-105. doi: 10.1002/dvdy.20205.
7
In vivo regulation of the early embryonic cell cycle in Xenopus.非洲爪蟾早期胚胎细胞周期的体内调控
Dev Biol. 1996 Feb 1;173(2):408-19. doi: 10.1006/dbio.1996.0036.
8
[From ovocyte to biochemistry of the cell cycle].[从卵母细胞到细胞周期的生物化学]
Verh K Acad Geneeskd Belg. 1991;53(4):365-85.
9
Behavior of the components of maturation-promoting factor, cdc2 kinase and cyclin B, during oocyte maturation of goldfish.金鱼卵母细胞成熟过程中成熟促进因子的组成成分cdc2激酶和细胞周期蛋白B的行为
Dev Biol. 1993 Nov;160(1):99-107. doi: 10.1006/dbio.1993.1289.
10
[Control of cell proliferation: towards new strategies suggested by modelling the mitotic oscillator].[细胞增殖的控制：基于有丝分裂振荡器建模提出的新策略]
Pathol Biol (Paris). 1996 Mar;44(3):172-8.
引用本文的文献
1
Mechanistic modeling of cell viability assays with in silico lineage tracing.采用计算机模拟谱系追踪的细胞活力测定的机制建模
PLoS Comput Biol. 2025 Aug 29;21(8):e1013156. doi: 10.1371/journal.pcbi.1013156. eCollection 2025 Aug.
2
Curating models from BioModels: Developing a workflow for creating OMEX files.从生物模型库精选模型：开发创建OMEX文件的工作流程。
PLoS One. 2024 Dec 5;19(12):e0314875. doi: 10.1371/journal.pone.0314875. eCollection 2024.
3
From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling.从采样到模拟：系统病理生理建模中的单细胞多组学
iScience. 2024 Nov 5;27(12):111322. doi: 10.1016/j.isci.2024.111322. eCollection 2024 Dec 20.
4
Expressive rule-based modeling and fast simulation for dynamic compartments.动态腔室的基于表达规则的建模和快速仿真。
PLoS One. 2024 Oct 31;19(10):e0312813. doi: 10.1371/journal.pone.0312813. eCollection 2024.
5
Cell Cycle Complexity: Exploring the Structure of Persistent Subsystems in 414 Models.细胞周期复杂性：探索414个模型中持久子系统的结构
Biomedicines. 2024 Oct 14;12(10):2334. doi: 10.3390/biomedicines12102334.
6
Selenium catalysis enables negative feedback organic oscillators.硒催化可实现负反馈有机振荡器。
Nat Commun. 2024 Apr 17;15(1):3316. doi: 10.1038/s41467-024-47714-6.
7
Curating models from BioModels: Developing a workflow for creating OMEX files.从生物模型库中精选模型：开发创建OMEX文件的工作流程。
bioRxiv. 2024 Nov 6:2024.03.15.585236. doi: 10.1101/2024.03.15.585236.
8
Design patterns of biological cells.生物细胞的设计模式。
Bioessays. 2024 Mar;46(3):e2300188. doi: 10.1002/bies.202300188. Epub 2024 Jan 21.
9
A model of replicating coupled oscillators generates naturally occurring cell networks.复制耦合振荡器模型生成自然发生的细胞网络。
Development. 2023 Nov 15;150(22). doi: 10.1242/dev.202187. Epub 2023 Nov 13.
10
Computing all persistent subspaces of a reaction-diffusion system.计算反应扩散系统的所有持久子空间。
Sci Rep. 2023 Oct 11;13(1):17169. doi: 10.1038/s41598-023-44244-x.
本文引用的文献
1
MACROMOLECULE SYNTHESIS AND THE INFLUENCE OF ACTINOMYCIN ON EARLY DEVELOPMENT.大分子合成及放线菌素对早期发育的影响
Exp Cell Res. 1964 Feb;33:368-95. doi: 10.1016/0014-4827(64)90002-3.
2
A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.一种与非洲爪蟾卵分裂周期具有相同周期的细胞质时钟。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):462-6. doi: 10.1073/pnas.77.1.462.
3
Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.非洲爪蟾卵母细胞和卵中一种M期特异性细胞质因子的细胞周期动力学
J Cell Biol. 1984 Apr;98(4):1247-55. doi: 10.1083/jcb.98.4.1247.
4
Regulation of the cell cycle during early Xenopus development.非洲爪蟾早期发育过程中细胞周期的调控。
Cell. 1984 Jul;37(3):731-42. doi: 10.1016/0092-8674(84)90409-4.
5
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.非洲爪蟾早期胚胎发育中的一个主要转变：I. 囊胚中期细胞变化的特征与时间进程
Cell. 1982 Oct;30(3):675-86. doi: 10.1016/0092-8674(82)90272-0.
6
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division.细胞周期蛋白：一种由海胆卵中母源mRNA所指定的蛋白质，在每次卵裂时都会被降解。
Cell. 1983 Jun;33(2):389-96. doi: 10.1016/0092-8674(83)90420-8.
7
Molecular basis of control of mitotic cell division in eukaryotes.真核生物中有丝分裂细胞分裂控制的分子基础。
Nature. 1974 Jun 7;249(457):553-6. doi: 10.1038/249553a0.
8
The cell cycle.细胞周期。
Sci Am. 1974 Jan;230(1):53-64.
9
cdc25+ functions as an inducer in the mitotic control of fission yeast.cdc25+在裂殖酵母的有丝分裂控制中作为诱导剂发挥作用。
Cell. 1986 Apr 11;45(1):145-53. doi: 10.1016/0092-8674(86)90546-5.
10
Maturation promoting factor and cell cycle regulation.成熟促进因子与细胞周期调控
J Embryol Exp Morphol. 1985 Nov;89 Suppl:271-84.
Zotero 插件