Tyson J J
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7328-32. doi: 10.1073/pnas.88.16.7328.
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
蛋白质cdc2和细胞周期蛋白形成一种异二聚体（成熟促进因子），它控制着细胞周期的主要事件。构建了一个关于cdc2和细胞周期蛋白相互作用的数学模型。对该模型的模拟和分析表明，控制系统可以以三种模式运行：作为具有高成熟促进因子活性的稳态、作为自发振荡器或作为可兴奋开关。我们将稳态与未受精卵中的中期停滞相关联，将自发振荡与早期胚胎中的快速分裂周期相关联，将可兴奋开关与非胚胎细胞典型的生长控制分裂周期相关联。
