Quartier Pierre, Prieur Anne-Marie
Unité d'Immunologie-Hématologie et Rhumatologie Pédiatrique, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris cedex 15, France.
Curr Rheumatol Rep. 2002 Dec;4(6):483-93. doi: 10.1007/s11926-002-0054-5.
Many conditions can cause or be associated with arthritis in childhood. The authors of this paper will review the situations in which underlying immunodeficiency or defective regulation of lymphocyte homeostasis must be suspected, and discuss, for some of these diseases, the genetic bases and pathogenesis. In the second part of this article, the authors will focus on other diseases that can cause arthritis in childhood, often with other symptoms, and for which evidence of an association with genetic abnormalities has been recently discovered. Finally, the authors will discuss the implications of recent findings regarding the role of some genes as causing or modulating factors in juvenile idiopathic arthritis and related disorders, as well as observations made in adults and in animal models of inflammation and autoimmunity.
许多病症可导致儿童患关节炎或与儿童关节炎相关。本文作者将回顾那些必须怀疑存在潜在免疫缺陷或淋巴细胞稳态调节缺陷的情况，并针对其中一些疾病讨论其遗传基础和发病机制。在本文的第二部分，作者将重点关注其他可导致儿童患关节炎的疾病，这些疾病通常伴有其他症状，且最近已发现其与基因异常有关的证据。最后，作者将讨论最近关于某些基因在幼年特发性关节炎及相关疾病中作为致病或调节因素所起作用的研究结果，以及在成人和炎症与自身免疫动物模型中的观察结果。
