Alvarez Guy E, Beske Stacy D, Ballard Tasha P, Davy Kevin P
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216, USA.
Circulation. 2002 Nov 12;106(20):2533-6. doi: 10.1161/01.cir.0000041244.79165.25.
Muscle sympathetic nerve activity (MSNA) is elevated in obese humans. However, the potential role of abdominal visceral fat as an important adipose tissue depot linking obesity to elevated MSNA has not been explored. Accordingly, we tested the hypothesis that MSNA would be increased in men (age=18 to 40 years, body mass index < or =35 kg/m2) with higher abdominal visceral fat (HAVF; n=13, abdominal visceral fat=118.1+/-15.8 cm2) compared with their age- (28.7+/-2.4 versus 25.5+/-2.0 years, P>0.05), total fat mass-matched (20.6+/-2.1 versus 20.8+/-2.4 kg, P>0.05) and abdominal subcutaneous fat-matched (230.6+/-24.9 versus 261.4+/-34.8 cm(2), P>0.05) peers with lower abdominal visceral fat levels (LAVF; n=13, visceral fat= 73.0+/-6.0 cm2).
MSNA (microneurography), body composition (dual energy x-ray absorptiometry), and abdominal visceral and subcutaneous fat (computed tomography) were measured in 37 sedentary men across a wide range of adiposity. MSNA was approximately 55% higher in men with HAVF compared with men with LAVF (33+/-4 versus 21+/-2 bursts/min, P<0.05). Furthermore, MSNA was more closely associated with the level of abdominal visceral fat (r=0.65, P<0.05) than total fat mass (r=0.323, P<0.05) or abdominal subcutaneous fat (r=0.27, P=0.05). The relation between MSNA and abdominal visceral fat was independent of total body fat (r=0.61, P<0.05).
The results of our study indicate that MSNA is elevated in men with visceral obesity. Our observations are consistent with the idea that abdominal visceral fat is an important adipose tissue depot linking obesity with sympathetic neural activation in humans. Furthermore, these findings may have important implications for understanding the increased risk of developing cardiovascular diseases in individuals with visceral obesity.
肥胖人群的肌肉交感神经活动（MSNA）增强。然而，腹部内脏脂肪作为将肥胖与升高的MSNA联系起来的重要脂肪组织储存库的潜在作用尚未得到探索。因此，我们检验了这样一种假设：与腹部内脏脂肪水平较低（LAVF；n = 13，内脏脂肪 = 73.0±6.0 cm²）的年龄匹配（28.7±2.4岁对25.5±2.0岁，P>0.05）、总脂肪量匹配（20.6±2.1 kg对20.8±2.4 kg，P>0.05）以及腹部皮下脂肪匹配（230.6±24.9 cm²对261.4±34.8 cm²，P>0.05）的男性相比，腹部内脏脂肪较高（HAVF；n = 13，腹部内脏脂肪 = 118.1±15.8 cm²）的男性（年龄 = 18至40岁，体重指数≤35 kg/m²）的MSNA会升高。
对37名久坐不动、肥胖程度各异的男性测量了MSNA（微神经图）、身体成分（双能X线吸收法）以及腹部内脏和皮下脂肪（计算机断层扫描）。与LAVF男性相比，HAVF男性的MSNA大约高55%（33±4次/分钟对21±2次/分钟，P<0.05）。此外，MSNA与腹部内脏脂肪水平的相关性（r = 0.65，P<0.05）比与总脂肪量（r = 0.323，P<0.05）或腹部皮下脂肪（r = 0.27，P = 0.05）的相关性更强。MSNA与腹部内脏脂肪之间的关系独立于全身脂肪（r = 0.61，P<0.05）。
我们的研究结果表明，内脏肥胖男性的MSNA升高。我们的观察结果与以下观点一致，即腹部内脏脂肪是将肥胖与人类交感神经激活联系起来的重要脂肪组织储存库。此外，这些发现可能对理解内脏肥胖个体患心血管疾病风险增加具有重要意义。
