Tomar Akash, Ahluwalia Himani, Ramkumar S, Pattnaik Sanghamitra, Nandi Debarshi, Raturi Prashant
Department of Physiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka.
Department of Physiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi.
Cardiovasc Endocrinol Metab. 2025 Jan 9;14(1):e00323. doi: 10.1097/XCE.0000000000000323. eCollection 2025 Mar.
The impact of obesity on heart rate variability (HRV) and ventricular repolarization, both vital indicators of cardiovascular health, is the focus of this review. Obesity, measured by BMI, waist circumference, and waist-to-hip ratio, significantly increases cardiovascular disease (CVD) risk due to structural and autonomic heart changes. Findings show that obese individuals exhibit prolonged QT and Tpeak-to-Tend (Tpe) intervals, suggesting delayed ventricular recovery and greater arrhythmia risk. Additionally, obesity-induced autonomic imbalance favors sympathetic activity over parasympathetic, reducing HRV and raising arrhythmogenic potential. Elevated QT and Tpe intervals reflect extended cardiac recovery phases, which contribute to poor cardiac outcomes. The Tpe interval could serve as an early marker of cardiac dysfunction in obese populations, highlighting the importance of early intervention to reduce CVD risk and enhance treatment strategies for obesity-related cardiovascular changes.
肥胖对心率变异性（HRV）和心室复极的影响是本综述的重点，而心率变异性和心室复极都是心血管健康的重要指标。通过体重指数（BMI）、腰围和腰臀比衡量的肥胖，由于心脏结构和自主神经的改变，会显著增加心血管疾病（CVD）风险。研究结果表明，肥胖个体的QT间期和T峰至T末（Tpe）间期延长，提示心室恢复延迟且心律失常风险更高。此外，肥胖引起的自主神经失衡使交感神经活动优于副交感神经，降低了心率变异性并增加了致心律失常的可能性。QT间期和Tpe间期延长反映了心脏恢复阶段的延长，这会导致不良的心脏结局。Tpe间期可作为肥胖人群心脏功能障碍的早期标志物，凸显了早期干预以降低心血管疾病风险和加强针对肥胖相关心血管变化的治疗策略的重要性。
