神经在肠道感染中的作用。
Role of nerves in enteric infection.
作者信息
Spiller R C
机构信息
Division of Gastroenterology, University Hospital, Nottingham, UK.
出版信息
Gut. 2002 Dec;51(6):759-62. doi: 10.1136/gut.51.6.759.
Abstract
Peripheral and central effects of enteric infection are considered. Nerves play a vital part in the immediate response to enteric infection, promoting pathogen expulsion by orchestrating intestinal secretion and propulsive motor patterns. Laboratory studies indicate that therapeutic agents aimed at modulating the neural response can profoundly alter the outcome of infection. As our understanding of the role of nerves increases, exciting new targets for therapeutic intervention will emerge in both acute and chronic disorders induced by enteric infection.
摘要
本文探讨了肠道感染的外周和中枢效应。神经在对肠道感染的即时反应中起着至关重要的作用，通过协调肠道分泌和推进性运动模式促进病原体排出。实验室研究表明，旨在调节神经反应的治疗药物可深刻改变感染的结局。随着我们对神经作用的理解不断加深，在由肠道感染引起的急性和慢性疾病中，都将出现令人兴奋的治疗干预新靶点。
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