• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Saccadic target selection deficits after lateral intraparietal area inactivation in monkeys.猴子顶叶内侧面区域失活后的扫视目标选择缺陷
J Neurosci. 2002 Nov 15;22(22):9877-84. doi: 10.1523/JNEUROSCI.22-22-09877.2002.
2
Effect of reversible inactivation of macaque lateral intraparietal area on visual and memory saccades.猕猴顶内沟外侧区可逆性失活对视觉和记忆性扫视的影响。
J Neurophysiol. 1999 Apr;81(4):1827-38. doi: 10.1152/jn.1999.81.4.1827.
3
Reversible inactivation of macaque frontal eye field.猕猴额叶眼区的可逆性失活
Exp Brain Res. 1997 Sep;116(2):229-49. doi: 10.1007/pl00005752.
4
Inactivation of macaque lateral intraparietal area delays initiation of the second saccade predominantly from contralesional eye positions in a double-saccade task.猕猴顶内沟外侧区失活主要在双眼跳任务中从对侧眼位延迟第二个扫视的起始。
Exp Brain Res. 2001 Mar;137(1):45-57. doi: 10.1007/s002210000546.
5
Muscimol-induced inactivation of monkey frontal eye field: effects on visually and memory-guided saccades.蝇蕈醇诱导的猴额叶眼动区失活：对视觉和记忆引导扫视的影响。
J Neurophysiol. 1999 May;81(5):2191-214. doi: 10.1152/jn.1999.81.5.2191.
6
Motor intention activity in the macaque's lateral intraparietal area. I. Dissociation of motor plan from sensory memory.猕猴外侧顶内沟区的运动意图活动。I. 运动计划与感觉记忆的分离。
J Neurophysiol. 1996 Sep;76(3):1439-56. doi: 10.1152/jn.1996.76.3.1439.
7
Effects of reversible inactivation of the primate mesencephalic reticular formation. I. Hypermetric goal-directed saccades.灵长类中脑网状结构可逆性失活的影响。I. 超距目标导向性扫视。
J Neurophysiol. 2000 Apr;83(4):2260-84. doi: 10.1152/jn.2000.83.4.2260.
8
Deficits in saccade target selection after inactivation of superior colliculus.上丘失活后扫视目标选择的缺陷。
Nat Neurosci. 2004 Jul;7(7):757-63. doi: 10.1038/nn1269. Epub 2004 Jun 13.
9
Motor intention activity in the macaque's lateral intraparietal area. II. Changes of motor plan.猕猴外侧顶内沟区域的运动意图活动。II. 运动计划的变化。
J Neurophysiol. 1996 Sep;76(3):1457-64. doi: 10.1152/jn.1996.76.3.1457.
10
Parietal representation of object-based saccades.基于物体的扫视的顶叶表征。
J Neurophysiol. 2002 Oct;88(4):1815-29. doi: 10.1152/jn.2002.88.4.1815.

引用本文的文献

1
Distinct neural population code and causal roles of primate caudate nucleus in multimodal decision-making.灵长类动物尾状核在多模态决策中的独特神经群体编码及因果作用。
Nat Commun. 2025 Jun 6;16(1):5253. doi: 10.1038/s41467-025-60504-y.
2
Orienting Gaze Toward a Visual Target: Neurophysiological Synthesis with Epistemological Considerations.将目光指向视觉目标：基于认识论考量的神经生理学综合研究
Vision (Basel). 2025 Jan 14;9(1):6. doi: 10.3390/vision9010006.
3
Organizing space through saccades and fixations between primate posterior parietal cortex and hippocampus.通过灵长类动物后顶叶皮层和海马体之间的扫视和注视来组织空间。
Nat Commun. 2024 Dec 1;15(1):10448. doi: 10.1038/s41467-024-54736-7.
4
Dorsal pulvinar inactivation leads to spatial selection bias without perceptual deficit.背侧丘觉核失活导致空间选择偏向而无感觉缺失。
Sci Rep. 2024 Jun 4;14(1):12852. doi: 10.1038/s41598-024-62056-5.
5
Decision-related activity and movement selection in primate visual cortex.灵长类视觉皮层中的决策相关活动和运动选择。
Sci Adv. 2024 May 31;10(22):eadk7214. doi: 10.1126/sciadv.adk7214. Epub 2024 May 29.
6
Laminar Dynamics of Target Selection in the Posterior Parietal Cortex of the Common Marmoset.恒河猴后顶叶皮层中目标选择的层流动力学。
J Neurosci. 2024 May 22;44(21):e1583232024. doi: 10.1523/JNEUROSCI.1583-23.2024.
7
Neuronal activity in posterior parietal cortex area LIP is not sufficient for saccadic eye movement production.后顶叶皮质LIP区的神经元活动对于产生眼球跳动运动并不充分。
Front Integr Neurosci. 2023 Nov 24;17:1251431. doi: 10.3389/fnint.2023.1251431. eCollection 2023.
8
Posterior Parietal Cortex Plays a Causal Role in Abstract Memory-Based Visual Categorical Decisions.后顶叶皮层在基于抽象记忆的视觉类别决策中起因果作用。
J Neurosci. 2023 Jun 7;43(23):4315-4328. doi: 10.1523/JNEUROSCI.2241-22.2023. Epub 2023 May 3.
9
Functional imaging and anatomical connections in squirrel monkeys reveal parietal-frontal circuits underlying eye movements.松鼠猴的功能成像和解剖连接揭示了眼球运动背后的顶叶-额叶回路。
Cereb Cortex. 2023 May 24;33(11):7258-7275. doi: 10.1093/cercor/bhad036.
10
Distractibility and impulsivity neural states are distinct from selective attention and modulate the implementation of spatial attention.注意力分散和冲动的神经状态与选择性注意不同，并且调节空间注意力的实施。
Nat Commun. 2022 Aug 15;13(1):4796. doi: 10.1038/s41467-022-32385-y.

本文引用的文献

1
Visual search performance in the neglect syndrome.忽视综合征的视觉搜索表现。
J Cogn Neurosci. 1989 Fall;1(4):372-85. doi: 10.1162/jocn.1989.1.4.372.
2
The role of the lateral intraparietal area of the monkey in the generation of saccades and visuospatial attention.猴子顶叶内侧面区域在扫视运动和视觉空间注意产生中的作用。
Ann N Y Acad Sci. 2002 Apr;956:205-15. doi: 10.1111/j.1749-6632.2002.tb02820.x.
3
Visual receptive field modulation in the lateral intraparietal area during attentive fixation and free gaze.在注意力集中注视和自由注视期间，顶内沟外侧区的视觉感受野调制
Cereb Cortex. 2002 Mar;12(3):234-45. doi: 10.1093/cercor/12.3.234.
4
Dynamic dissociation of visual selection from saccade programming in frontal eye field.额眼区视觉选择与扫视编程的动态分离
J Neurophysiol. 2001 Nov;86(5):2634-7. doi: 10.1152/jn.2001.86.5.2634.
5
Ipsilesional biases in saccades but not perception after lesions of the human inferior parietal lobule.人类顶下小叶损伤后扫视存在患侧偏向，但知觉不存在患侧偏向。
J Cogn Neurosci. 2001 Oct 1;13(7):920-9. doi: 10.1162/089892901753165836.
6
The lateral intraparietal area as a salience map: the representation of abrupt onset, stimulus motion, and task relevance.作为显著性图的顶内叶外侧区：突发起始、刺激运动及任务相关性的表征
Vision Res. 2000;40(10-12):1459-68. doi: 10.1016/s0042-6989(99)00212-6.
7
Muscimol-induced inactivation of monkey frontal eye field: effects on visually and memory-guided saccades.蝇蕈醇诱导的猴额叶眼动区失活：对视觉和记忆引导扫视的影响。
J Neurophysiol. 1999 May;81(5):2191-214. doi: 10.1152/jn.1999.81.5.2191.
8
Effect of reversible inactivation of macaque lateral intraparietal area on visual and memory saccades.猕猴顶内沟外侧区可逆性失活对视觉和记忆性扫视的影响。
J Neurophysiol. 1999 Apr;81(4):1827-38. doi: 10.1152/jn.1999.81.4.1827.
9
The effects of frontal eye field and dorsomedial frontal cortex lesions on visually guided eye movements.额叶眼区和背内侧前额叶皮质损伤对视觉引导眼球运动的影响。
Nat Neurosci. 1998 Jul;1(3):248-53. doi: 10.1038/693.
10
Pharmacological inactivation in the analysis of the central control of movement.运动中枢控制分析中的药理学失活
J Neurosci Methods. 1999 Jan;86(2):145-59. doi: 10.1016/s0165-0270(98)00163-0.

猴子顶叶内侧面区域失活后的扫视目标选择缺陷

Saccadic target selection deficits after lateral intraparietal area inactivation in monkeys.

作者信息

Wardak Claire, Olivier Etienne, Duhamel Jean-René

机构信息

Institut des Sciences Cognitives, Unité Mixte de Recherche 5015 Centre National de la Recherche Scientifique-Université Claude Bernard Lyon 1, 69675 Bron Cedex, France.

出版信息

J Neurosci. 2002 Nov 15;22(22):9877-84. doi: 10.1523/JNEUROSCI.22-22-09877.2002.

DOI:10.1523/JNEUROSCI.22-22-09877.2002
PMID:12427844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6757813/
Abstract

We investigated the contribution of the lateral intraparietal area (LIP) to the selection of saccadic eye movement targets and to saccade execution using muscimol-induced reversible inactivation and compared those effects with inactivation of the adjacent ventral intraparietal area (VIP) and with sham injections of saline into LIP. Three types of tasks were used: saccades to single visual or memorized targets, saccades to synchronous and asynchronous bilateral targets, and visual search of a target among distractors. LIP inactivation failed to produce deficits in the latency or accuracy of saccades to single targets, but it dramatically reduced the frequency of contralateral saccades in the presence of bilateral targets, and it increased search time for a contralateral target during serial visual search. In the latter task, the observed deficits might reflect either an ispilateral bias in saccadic search strategy or an attentional impairment in locating a target among flanking distractors within the contralateral field. No effects were observed on any of these tasks after VIP inactivation. These results suggest that one important contribution of LIP to oculomotor behavior is the selection of targets for saccades in the context of competing visual stimuli.

摘要

我们利用蝇蕈醇诱导的可逆性失活研究了顶内沟外侧区（LIP）对扫视眼动目标选择和扫视执行的作用，并将这些效应与相邻的腹侧顶内区（VIP）失活以及向LIP注射生理盐水的假注射效应进行了比较。使用了三种类型的任务：向单个视觉或记忆目标的扫视、向同步和异步双侧目标的扫视，以及在干扰物中对目标的视觉搜索。LIP失活并未导致向单个目标扫视的潜伏期或准确性出现缺陷，但在存在双侧目标时，它显著降低了对侧扫视的频率，并且在连续视觉搜索过程中增加了对侧目标的搜索时间。在后一种任务中，观察到的缺陷可能反映了扫视搜索策略中的同侧偏向，或者是在对侧视野内的侧翼干扰物中定位目标时的注意力损伤。VIP失活后，在这些任务中均未观察到任何效应。这些结果表明，LIP对眼球运动行为的一个重要作用是在竞争性视觉刺激的背景下选择扫视目标。