Prodan C I, Holland N R, Wisdom P J, Burstein S A, Bottomley S S
Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Neurology. 2002 Nov 12;59(9):1453-6. doi: 10.1212/01.wnl.0000032497.30439.f6.
CNS demyelination is not a previously reported feature of acquired copper deficiency. The authors report two patients with idiopathic hypocupremia and hyperzincemia, hematologic changes of copper deficiency, and extensive CNS demyelination. Hematologic recovery followed copper supplementation, both initially and after relapse off copper therapy, while serum zinc levels remained high and the neurologic abnormalities only stabilized.
中枢神经系统脱髓鞘并非先前报道的获得性铜缺乏的特征。作者报告了两名患有特发性低铜血症和高锌血症、铜缺乏的血液学改变以及广泛中枢神经系统脱髓鞘的患者。补充铜后血液学得到恢复，最初如此，在停止铜治疗复发后也是如此，而血清锌水平仍保持较高，神经学异常仅得到稳定。
