Möller-Hartmann W, Krings T, Hans F J, Thiex R, Meetz A, Stein K, Dreeskamp H, Gilsbach J M, Thron A
Department of Neuroradiology, University Hospital of the University of Technology, Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Neuroradiology. 2002 Nov;44(11):946-9. doi: 10.1007/s00234-002-0870-3. Epub 2002 Oct 11.
The Guglielmi detachable coil (GDC) has been generally accepted for treatment of intracranial aneurysms. Preclinical testing of new coil developments requires animal models of aneurysms which imitate human aneurysms in size, configuration and neck morphology. We assessed in detail the technical requirements and steps for transfemoral treatment of experimentally induced aneurysms at the top of the brachiocephalic trunk (TBC) in rabbits. We created aneurysms in five rabbits by distal ligation and intraluminal incubation of the right common carotid artery with elastase. All animals were treated successfully 2-3 weeks after induction of the aneurysm, with dense packing of the coils. No complications related to the procedures occurred. The study demonstrates that our animal model can be a suitable method for testing the biocompatibility and occlusion rate of new embolic materials.
Guglielmi可脱卸弹簧圈（GDC）已被广泛接受用于治疗颅内动脉瘤。新型弹簧圈的临床前测试需要动脉瘤动物模型，该模型在大小、形态和颈部形态上模仿人类动脉瘤。我们详细评估了经股动脉治疗兔头臂干（TBC）顶端实验性诱导动脉瘤的技术要求和步骤。我们通过右侧颈总动脉远端结扎并腔内注入弹性蛋白酶，在5只兔身上制造了动脉瘤。所有动物在动脉瘤诱导后2至3周成功接受治疗，弹簧圈紧密填塞。未发生与手术相关的并发症。该研究表明，我们的动物模型可以作为测试新型栓塞材料生物相容性和闭塞率的合适方法。
