Hans F J, Krings T, Möller-Hartmann W, Thiex R, Pfeffer J, Scherer K, Brunn A, Dreeskamp H, Stein K P, Meetz A, Gilsbach J M, Thron A
Department of Neurosurgery, University Hospital of the University of Technology, Pauwelsstrasse 30, 52057, Aachen, Germany.
Neuroradiology. 2003 Jul;45(7):430-4. doi: 10.1007/s00234-003-1008-y. Epub 2003 May 22.
Although Guglielmi detachable coil (GDC) systems have been generally accepted for treatment of intracranial aneurysms, primary stenting of aneurysms using porous stents or implantation of coils after stent placement remains experimental. Testing of these new methods requires an animal model which imitates human aneurysms in size, configuration and neck morphology. We assessed in detail the technical requirements of and steps for transfemoral stent treatment of experimentally induced aneurysms at the top of the brachiocephalic trunk in rabbits. We created aneurysms in ten rabbits by distal ligation and intraluminal digestion of the right common carotid artery with elastase. We treated five animals with porous stents alone, and five with stents plus coiling via the meshes of the stent, which permitted dense packing of coils. No complications related to the procedures occurred. In all animals, even in those treated solely with porous stents, total occlusion of the aneurysm was achieved. Our animal model can be suitable for testing the biocompatibility and occlusion rate of new methods and devices for the treatment of experimental aneurysms.
尽管 Guglielmi 可脱卸弹簧圈（GDC）系统已被广泛用于治疗颅内动脉瘤，但使用多孔支架对动脉瘤进行初次支架置入或在支架置入后植入弹簧圈仍处于实验阶段。测试这些新方法需要一个在大小、形态和颈部形态上模拟人类动脉瘤的动物模型。我们详细评估了经股动脉对兔头臂干顶端实验性诱导动脉瘤进行支架治疗的技术要求和步骤。我们通过右颈总动脉远端结扎并用弹性蛋白酶进行腔内消化，在 10 只兔身上制造了动脉瘤。我们对 5 只动物仅使用多孔支架进行治疗，对另外 5 只动物通过支架网孔进行支架加弹簧圈置入治疗，这使得弹簧圈能够紧密填充。未发生与手术相关的并发症。在所有动物中，即使是仅接受多孔支架治疗的动物，动脉瘤也实现了完全闭塞。我们的动物模型可适用于测试治疗实验性动脉瘤的新方法和装置的生物相容性及闭塞率。
