Mamalakis G, Kafatos A, Manios Y, Kalogeropoulos N, Andrikopoulos N
School of Medicine, Department of Social Medicine Preventive Medicine and Nutrition, University of Crete, Iraklion, Crete, Greece.
Eur J Clin Nutr. 2002 Nov;56(11):1081-6. doi: 10.1038/sj.ejcn.1601438.
To explore the extent to which the reported unfavorable fatty acid content of abdominal depots in adults is also true for children. In addition, the present study aims to assess the relative importance of abdominal vs buttock adipose tissue fat in the prediction of serum lipid levels in children.
A cross-sectional study of children from the island of Crete.
The study was conducted between October 1999 and January 2000 in the Municipality of St Nikolas, Crete.
A total of 475 children (aged 11-18) participated in the study. Data were obtained on children's anthropometry, serum lipids, physical activity and abdominal and buttock adipose tissue fatty acids. In total 138 children (aged 11-16) had complete data in all of the variables studied.
Abdominal depots have elevated proportions of saturated fatty acids (P<0.001) and trans fatty acids (P<0.001), and reduced proportions of monounsaturated (P<0.001) and polyunsaturated fatty acids (P<0.001) in comparison to buttock depots. Buttock adipose tissue monounsaturated fat correlated negatively to serum LDL-C (P<0.05). Abdominal adipose tissue polyunsaturated fat had negative correlations with serum total cholesterol (P<0.05) and LDL-C (P<0.05). Regression analyses indicated that children's serum total cholesterol (P<0.05) and LDL-C (P<0.05) were inversely related to abdominal adipose tissue polyunsaturated fat. Body mass index was positively related to serum triglycerides (P<0.01) and LDL-C (P<0.01), and negatively to serum HDL-C (P<0.05). Age was negatively related to serum HDL-C (P<0.05).
It appears that, similar to adults, children's fatty acid composition of abdominal adipose tissue is less favorable than that of the buttock. Abdominal depots have elevated proportions of saturated fatty acids and reduced proportions of monounsaturated and polyunsaturated fat in comparison to buttock depots. Moreover, children's abdominal depots appear to have higher trans fatty acid contents than buttock depots. Children's adipose polyunsaturated fat, a biomarker of long-term polyunsaturated fatty acid intake, is inversely related to serum total cholesterol and LDL-C. It appears that abdominal adipose tissue fatty acids are more strongly related to serum lipids than buttock adipose tissue fatty acids. This may be attributed to the reported higher lipolysis rates in abdominal as opposed to buttock depots.
Funding was provided by the Municipality of St Nikolas, Crete, Greece.
探讨有关成人腹部脂肪库中脂肪酸含量不利的报道在儿童中是否同样成立。此外，本研究旨在评估腹部与臀部脂肪组织脂肪在预测儿童血脂水平方面的相对重要性。
对来自克里特岛的儿童进行的横断面研究。
该研究于1999年10月至2000年1月在希腊克里特岛圣尼古拉斯市进行。
共有475名儿童（年龄11 - 18岁）参与了该研究。获取了有关儿童人体测量学、血脂、身体活动以及腹部和臀部脂肪组织脂肪酸的数据。共有138名儿童（年龄11 - 16岁）在所有研究变量上都有完整数据。
与臀部脂肪库相比，腹部脂肪库中饱和脂肪酸（P<0.001）和反式脂肪酸（P<0.001）的比例升高，而单不饱和脂肪酸（P<0.001）和多不饱和脂肪酸（P<0.001）的比例降低。臀部脂肪组织中的单不饱和脂肪与血清低密度脂蛋白胆固醇（LDL-C）呈负相关（P<0.05）。腹部脂肪组织中的多不饱和脂肪与血清总胆固醇（P<0.05）和LDL-C（P<0.05）呈负相关。回归分析表明，儿童的血清总胆固醇（P<0.05）和LDL-C（P<0.05）与腹部脂肪组织中的多不饱和脂肪呈负相关。体重指数与血清甘油三酯（P<0.01）和LDL-C（P<0.01）呈正相关，与血清高密度脂蛋白胆固醇（HDL-C）呈负相关（P<0.05）。年龄与血清HDL-C呈负相关（P<0.05）。
与成人相似，儿童腹部脂肪组织的脂肪酸组成似乎不如臀部的有利。与臀部脂肪库相比，腹部脂肪库中饱和脂肪酸比例升高，单不饱和脂肪酸和多不饱和脂肪比例降低。此外，儿童腹部脂肪库中的反式脂肪酸含量似乎高于臀部脂肪库。儿童脂肪组织中的多不饱和脂肪是长期多不饱和脂肪酸摄入量的生物标志物，与血清总胆固醇和LDL-C呈负相关。似乎腹部脂肪组织脂肪酸与血脂的关系比臀部脂肪组织脂肪酸更密切。这可能归因于报道的腹部脂肪库与臀部脂肪库相比更高的脂肪分解率。
由希腊克里特岛圣尼古拉斯市提供资金。
