Aleeva G N, Kiyasov A P, Minnebaev M M, Burykin I M, Khafiz'yanova R Kh
Department of Normal Human Anatomy, Department of Pathophysiology, Department of Pharmacology, Kazan State Medical University.
Bull Exp Biol Med. 2002 Feb;133(2):127-9. doi: 10.1023/a:1015578201402.
We estimated the count of pancreatic alpha- and beta-cells and blood glucose level at various stages of alloxan-induced diabetes in rats. Alloxan decreased the count of insulin-producing beta-cells, but increased the number of glucagon-secreting alpha-cells in the pancreas (week 1 of diabetes). These changes were accompanied by hyperglycemia. The decrease in blood glucose level in diabetic rats was associated with an increase in beta-cell count against the background of high density of pancreatic alpha-cells.
我们估算了大鼠在四氧嘧啶诱导的糖尿病各个阶段胰腺α细胞和β细胞的数量以及血糖水平。四氧嘧啶减少了胰腺中产生胰岛素的β细胞数量，但增加了分泌胰高血糖素的α细胞数量（糖尿病第1周）。这些变化伴随着高血糖症。糖尿病大鼠血糖水平的降低与在胰腺α细胞高密度背景下β细胞数量的增加有关。
