Lahey Benjamin B, Loeber Rolf, Burke Jeffrey, Rathouz Paul J, McBurnett Keith
Department of Psychiatry, University of Chicago, Illinois 60637, USA.
J Abnorm Psychol. 2002 Nov;111(4):556-67. doi: 10.1037//0021-843x.111.4.556.
Six waves of structured diagnostic assessments were conducted of 168 clinic-referred 7- to 12-year-olds, over 7 years. Wave-to-wave changes in the number of conduct disorder (CD) behaviors were paralleled by correlated changes in the numbers of symptoms of oppositional defiant disorder (ODD), attention-deficit/hyperactivity disorder (ADHD), depression, and anxiety. In addition, CD in Wave 1 predicted levels of ODD, ADHD, depression, and anxiety in later waves when initial levels of those symptoms were controlled, but only ODD in Wave 1 predicted CD in later waves when initial CD levels were controlled. These findings indicate a striking degree of dynamic comorbidity between CD and other types of psychopathology and provide an initial empirical framework for needed developmental models of comorbidity.
在7年时间里，对168名7至12岁前来诊所就诊的儿童进行了六轮结构化诊断评估。品行障碍（CD）行为数量的逐轮变化与对立违抗障碍（ODD）、注意力缺陷多动障碍（ADHD）、抑郁和焦虑症状数量的相关变化并行。此外，在控制了这些症状的初始水平后，第1轮的CD预测了后续轮次中ODD、ADHD、抑郁和焦虑的水平，但在控制了初始CD水平后，只有第1轮的ODD预测了后续轮次中的CD。这些发现表明CD与其他类型精神病理学之间存在显著程度的动态共病现象，并为所需的共病发展模型提供了初步的实证框架。
