Aubeny E, Buhler M, Colau J C, Vicaut E, Zadikian M, Childs M
Hĵpital de Sèvres, Paris, France.
Eur J Contracept Reprod Health Care. 2002 Sep;7(3):155-61.
To determine the number of times women failed to take their oral contraceptive medication and their behavior in response to a missed pill. Another objective was to determine the potential benefit provided by a continuously administered oral contraceptive compared with an oral contraceptive involving a pill-free interval during a 6-month period.
Healthy women were enrolled in a cohort study; their contraceptive practices were followed by their gynecologists. Data were collected at inclusion using cross-sectional method with retrospective data collection for the previous 6 months and, more specifically, on their previous or their current menstrual cycle. Women on the pill were asked to specify the number of times and precise time at which they missed one or more pills and what they did in response to missing a pill.
A total of 617 gynecologists enrolled and followed 3316 patients from six geographic areas throughout France. The mean age of patients was 30 years. Duration of oral contraceptive use was 8 years. During their previous cycle, 23% of women (n = 737) missed a pill at least once. Among women on the pill involving a treatment-free interval, 42% of instances of missing a pill occurred during the first week following the treatment-free interval. In response to missing a pill, patients read the product information leaflet (39%) or asked someone's advice (28%), mainly their gynecologist (63%) or their family physician (18%). Almost one-third of women did not take any specific measures.
Patients on a discontinuous oral contraceptive regimen tended to miss a pill during the first week of treatment. Prescription of a continuous regimen without a treatment-free interval may improve compliance.
确定女性漏服口服避孕药的次数及其应对漏服药物的行为。另一个目的是确定在6个月期间，持续服用的口服避孕药与有停药间隔的口服避孕药相比所具有的潜在益处。
健康女性参与一项队列研究；其避孕措施由妇科医生跟踪。采用横断面方法在纳入研究时收集数据，并回顾性收集前6个月的数据，更具体地说，是关于她们之前或当前的月经周期。服用避孕药的女性被要求说明漏服一粒或多粒药物的次数和准确时间，以及她们对漏服药物的应对措施。
共有617名妇科医生登记并跟踪了来自法国六个地理区域的3316名患者。患者的平均年龄为30岁。口服避孕药的使用时长为8年。在前一个周期中，23%的女性（n = 737）至少漏服过一次药。在服用有停药间隔的避孕药的女性中，42%的漏服情况发生在停药间隔后的第一周。对于漏服药物，患者会阅读产品说明书（39%）或向他人咨询（28%），主要是向妇科医生（63%）或家庭医生（18%）咨询。近三分之一的女性未采取任何具体措施。
采用间断口服避孕药方案的患者在治疗的第一周往往会漏服药物。开具无停药间隔的持续用药方案可能会提高依从性。
