Ahlberg Ann-Charlotte, Ljung Thomas, Rosmond Roland, McEwen Bruce, Holm Göran, Akesson Hans Olof, Björntorp Per
Department of Psychiatry, Sahlgrenska University Hospital, University of Göteborg, Sweden.
Psychiatry Res. 2002 Oct 10;112(2):101-10. doi: 10.1016/s0165-1781(02)00192-0.
Depression is associated with an increased risk of developing cardiovascular disease and type 2 diabetes mellitus. Abdominal obesity is also a high risk factor for these diseases. Therefore, symptoms of depression and anxiety were examined in relation to abdominal obesity. A total of 59 middle-aged men volunteered for measurements with the Hamilton Depression Scale (HDS), the Montgomery-Asberg Depression Rating Scale (MADRS), the Beck Depression Inventory (BDI) and the Hamilton Anxiety Scale (HAS). These results were examined in relation to body mass index (BMI), waist/hip ratio (WHR) and sagittal abdominal diameter, a measurement of intra-abdominal fat mass, and metabolic variables. Men with WHR>1.0 (n=26) in comparison with men with normal WHR (<1.0, n=33) showed significantly higher sum scores in all the scales used. There were positive correlations between the sum scores of all the depression scales and the WHR or the sagittal abdominal diameter. BMI correlated comparatively weakly only with the HDS. The correlations with the WHR remained when the influence of BMI was eliminated, suggesting that obesity is less involved than centralization of body fat. Insulin and glucose were significantly related to the HDS. Morning cortisol levels were negatively related to the BDI and (borderline) to the MADRS, suggesting perturbations of the regulation of the hypothalamic-pituitary-adrenal axis. We conclude that men with abdominal obesity have symptoms of depression and anxiety.
抑郁症与患心血管疾病和2型糖尿病的风险增加有关。腹部肥胖也是这些疾病的一个高危因素。因此，对抑郁症和焦虑症的症状与腹部肥胖的关系进行了研究。共有59名中年男性自愿接受汉密尔顿抑郁量表（HDS）、蒙哥马利-艾森伯格抑郁评定量表（MADRS）、贝克抑郁量表（BDI）和汉密尔顿焦虑量表（HAS）的测量。这些结果与体重指数（BMI）、腰臀比（WHR）和矢状腹径（一种腹部脂肪量的测量方法）以及代谢变量进行了比较。与腰臀比正常（<1.0，n = 33）的男性相比，腰臀比>1.0（n = 26）的男性在所有使用的量表中总分显著更高。所有抑郁量表的总分与腰臀比或矢状腹径之间存在正相关。BMI仅与HDS的相关性相对较弱。消除BMI的影响后，与腰臀比的相关性仍然存在，这表明肥胖的影响小于体脂的中心分布。胰岛素和葡萄糖与HDS显著相关。早晨皮质醇水平与BDI呈负相关，与MADRS呈（临界）负相关，提示下丘脑-垂体-肾上腺轴调节紊乱。我们得出结论，腹部肥胖的男性有抑郁和焦虑症状。
