使用可生物降解聚合物薄膜进行组织焊接——体内急性强度增强的演示
Tissue welding with biodegradable polymer films-demonstration of acute strength reinforcement in vivo.
作者信息
Sorg Brian S, Welch Ashley J
机构信息
Biomedical Engineering Program, University of Texas at Austin, Austin, Texas 78712, USA.
出版信息
Lasers Surg Med. 2002;31(5):339-42. doi: 10.1002/lsm.10123.
BACKGROUND AND OBJECTIVES
To demonstrate, in vivo, acute strength reinforcement benefits of polymer film patches.
STUDY DESIGN/MATERIALS AND METHODS: Full thickness incisions created in a dorsal skin flap of Sprague-Dawley rats were closed by laser-tissue welding: albumin solder was topically applied to the incision on the dermal surface, and a poly(lactic-co-glycolic acid) (PLGA) polymer film placed on the solder as a patch (controls had no film). Breaking strength was tested acutely (15-20 minutes after sacrifice).
RESULTS
The patched incisions were statistically stronger than the controls (ANOVA, P < 0.05).
CONCLUSIONS
Polymer film patches may be a viable method to increase acute breaking strengths of welds using topically applied solder.
背景与目的
在活体中证明聚合物薄膜贴片的急性强度增强益处。
研究设计/材料与方法：在Sprague-Dawley大鼠背部皮瓣上制作全层切口，通过激光组织焊接进行闭合：将白蛋白焊剂局部涂抹于真皮表面的切口上，并将聚乳酸-乙醇酸共聚物（PLGA）聚合物薄膜作为贴片置于焊剂上（对照组无薄膜）。在处死动物后15 - 20分钟急性测试抗张强度。
结果
贴片切口在统计学上比对照组更强（方差分析，P < 0.05）。
结论
聚合物薄膜贴片可能是一种可行的方法，可提高使用局部涂抹焊剂的焊接的急性抗张强度。
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