Ebel H, Classen H G
Arzneimittelforschung. 1975 Oct;25(10):1610-21.
From 1949 to 1974, urine samples of 1669 patients with unclarified arterial hypertension were tested for non-conjugated catecholamines. Chromaffine tumours--among them one pheochromoblastoma and two families with inherited forms--were found in 1.1% of all cases. With the procedure applied, adrenergic alpha- and/or beta-mimetic actions on the circulation of cats can be identified when the excretion of total catecholamines is increased by the factor 1.5 to 2.0. Hence, chromaffine tumours with smaller excretion rates (about 200 mug/24 h) are also detectable, so in one case where the excretion of vanillyl-mandelic acid was normal. Thus all prerequisites concerning sensitivity and specificity of a screening method are fulfilled. The large variety of symptoms of chromaffine tumours becomes obvious from the catamnestic data of 19 patients indicating problems which may arise in differential diagnosis.
1949年至1974年期间，对1669例不明原因的动脉高血压患者的尿液样本进行了非共轭儿茶酚胺检测。在所有病例中，发现嗜铬细胞瘤（其中1例为嗜铬细胞瘤，2个家族为遗传性形式）的比例为1.1%。采用该方法，当总儿茶酚胺排泄量增加1.5至2.0倍时，可识别肾上腺素能α和/或β模拟物对猫循环系统的作用。因此，排泄率较低（约200μg/24小时）的嗜铬细胞瘤也可被检测到，例如在1例香草扁桃酸排泄正常的病例中。因此，一种筛查方法在敏感性和特异性方面的所有前提条件均已满足。从19例患者的病史数据中可以明显看出嗜铬细胞瘤症状的多样性，这些数据表明了鉴别诊断中可能出现的问题。
