• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

衰老会重塑下丘脑视上核的转录组，并改变对脱水的反应。

Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration.

作者信息

Elsamad Ghadir, Mecawi André Souza, Pauža Audrys G, Gillard Benjamin, Paterson Alex, Duque Victor J, Šarenac Olivera, Žigon Nina Japundžić, Greenwood Mingkwan, Greenwood Michael P, Murphy David

机构信息

Molecular Neuroendocrinology Research Group, Bristol Medical School: Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, England.

Laboratory of Molecular Neuroendocrinology, Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.

出版信息

NPJ Aging. 2023 Jun 1;9(1):12. doi: 10.1038/s41514-023-00108-2.

DOI:10.1038/s41514-023-00108-2
PMID:37264028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10234251/
Abstract

Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more susceptible to dehydration. Chronically, vasopressin has been associated with numerous diseases of old age, including type 2 diabetes and metabolic syndrome. Bulk RNAseq transcriptome analysis has been used to catalogue the polyadenylated supraoptic nucleus transcriptomes of adult (3 months) and aged (18 months) rats in basal euhydrated and stimulated dehydrated conditions. Gene ontology and Weighted Correlation Network Analysis revealed that ageing is associated with alterations in the expression of extracellular matrix genes. Interestingly, whilst the transcriptomic response to dehydration is overall blunted in aged animals compared to adults, there is a specific enrichment of differentially expressed genes related to neurodegenerative processes in the aged cohort, suggesting that dehydration itself may provoke degenerative consequences in aged rats.

摘要

衰老与神经内分泌功能改变有关。在下丘脑视上核（该核产生抗利尿激素血管加压素）的背景下，衰老会改变对高渗刺激的急性反应，使老年人更容易脱水。长期来看，血管加压素与多种老年疾病有关，包括2型糖尿病和代谢综合征。大量RNA测序转录组分析已被用于编目成年（3个月）和老年（18个月）大鼠在基础水合和刺激脱水条件下视上核的多聚腺苷酸化转录组。基因本体论和加权相关网络分析表明，衰老与细胞外基质基因表达的改变有关。有趣的是，虽然与成年动物相比，老年动物对脱水的转录组反应总体上减弱，但在老年队列中与神经退行性过程相关的差异表达基因有特定富集，这表明脱水本身可能在老年大鼠中引发退行性后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/d0ec025796ff/41514_2023_108_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/5bf781e9444d/41514_2023_108_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/de808c9e04b6/41514_2023_108_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/f1fca2a778a1/41514_2023_108_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/646f8923e33c/41514_2023_108_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/5220ec6eb2d5/41514_2023_108_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/f5f4c7fdfccc/41514_2023_108_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/d0ec025796ff/41514_2023_108_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/5bf781e9444d/41514_2023_108_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/de808c9e04b6/41514_2023_108_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/f1fca2a778a1/41514_2023_108_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/646f8923e33c/41514_2023_108_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/5220ec6eb2d5/41514_2023_108_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/f5f4c7fdfccc/41514_2023_108_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afc/10235046/d0ec025796ff/41514_2023_108_Fig7_HTML.jpg

相似文献

1
Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration.衰老会重塑下丘脑视上核的转录组，并改变对脱水的反应。
NPJ Aging. 2023 Jun 1;9(1):12. doi: 10.1038/s41514-023-00108-2.
2
Dominant dystrophic epidermolysis bullosa is associated with glycolytically active GATA3+ T helper 2 cells which may contribute to pruritus in lesional skin.显性营养不良型大疱性表皮松解症与糖酵解活性的 GATA3+T 辅助 2 细胞相关，这些细胞可能导致皮损皮肤的瘙痒。
Br J Dermatol. 2024 Jul 16;191(2):252-260. doi: 10.1093/bjd/ljae110.
3
Exome and transcriptome analysis link calcium channel pathway aberrations to botulinum toxin A resistance in Hailey-Hailey disease.外显子组和转录组分析将钙通道途径异常与黑利-黑利病中肉毒杆菌毒素A耐药性联系起来。
Br J Dermatol. 2025 Jun 20;193(1):147-156. doi: 10.1093/bjd/ljaf112.
4
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
5
Effectiveness and safety of vitamin D in relation to bone health.维生素D对骨骼健康的有效性与安全性。
Evid Rep Technol Assess (Full Rep). 2007 Aug(158):1-235.
6
Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature.吸入装置在哮喘和慢性阻塞性气道疾病中的有效性比较：文献系统评价
Health Technol Assess. 2001;5(26):1-149. doi: 10.3310/hta5260.
7
Parent-training programmes for improving maternal psychosocial health.改善孕产妇心理社会健康的家长培训项目。
Cochrane Database Syst Rev. 2004(1):CD002020. doi: 10.1002/14651858.CD002020.pub2.
8
Cumulative methotrexate dose is not associated with liver fibrosis in patients with a history of moderate-to-severe psoriasis.累积甲氨蝶呤剂量与有中重度银屑病病史患者的肝纤维化无关。
Br J Dermatol. 2024 Jul 16;191(2):275-283. doi: 10.1093/bjd/ljae069.
9
Running shoes for preventing lower limb running injuries in adults.预防成年人下肢跑步损伤的跑鞋。
Cochrane Database Syst Rev. 2022 Aug 22;8(8):CD013368. doi: 10.1002/14651858.CD013368.pub2.
10
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.

引用本文的文献

1
Body fluid regulation.体液调节
Curr Opin Neurobiol. 2025 Jun;92:103017. doi: 10.1016/j.conb.2025.103017. Epub 2025 Apr 2.
2
Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity.视上核的转录组和甲基化组为神经元可塑性随年龄增长而丧失提供了见解。
Front Aging Neurosci. 2023 Aug 30;15:1223273. doi: 10.3389/fnagi.2023.1223273. eCollection 2023.

本文引用的文献

1
Age-Associated Abnormalities of Water Homeostasis.与年龄相关的水稳态异常。
Endocrinol Metab Clin North Am. 2023 Jun;52(2):277-293. doi: 10.1016/j.ecl.2022.11.002. Epub 2023 Feb 19.
2
Single-cell analysis of the aging female mouse hypothalamus.衰老雌性小鼠下丘脑的单细胞分析。
Nat Aging. 2022 Jul;2(7):662-678. doi: 10.1038/s43587-022-00246-4. Epub 2022 Jul 4.
3
Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells.转录因子 Creb3l1 维持神经内分泌细胞的蛋白质平衡。
Mol Metab. 2022 Sep;63:101542. doi: 10.1016/j.molmet.2022.101542. Epub 2022 Jul 6.
4
Osmoregulation and the Hypothalamic Supraoptic Nucleus: From Genes to Functions.渗透调节与下丘脑视上核：从基因到功能
Front Physiol. 2022 May 24;13:887779. doi: 10.3389/fphys.2022.887779. eCollection 2022.
5
Regulation of Translation, Translocation, and Degradation of Proteins at the Membrane of the Endoplasmic Reticulum.内质网膜上蛋白质的翻译、易位和降解的调控。
Int J Mol Sci. 2022 May 17;23(10):5576. doi: 10.3390/ijms23105576.
6
Copeptin as a marker of atherosclerosis and arteriosclerosis. copeptin 作为动脉粥样硬化和动脉硬化的标志物。
Atherosclerosis. 2021 Dec;338:64-68. doi: 10.1016/j.atherosclerosis.2021.10.012. Epub 2021 Nov 1.
7
Osmoregulation of the transcriptome of the hypothalamic supraoptic nucleus: A resource for the community.下丘脑视上核转录组的渗透调节：社区资源
J Neuroendocrinol. 2021 Jun 22;33(8):e13007. doi: 10.1111/jne.13007.
8
The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration.健康衰老和神经退行性变中的视上核和室旁核。
Handb Clin Neurol. 2021;180:105-123. doi: 10.1016/B978-0-12-820107-7.00007-0.
9
A Journey through the Early Evidence Linking Hydration to Metabolic Health.水合作用与代谢健康早期关联证据的探索之旅。
Ann Nutr Metab. 2020;76 Suppl 1:4-9. doi: 10.1159/000515021. Epub 2021 Mar 26.
10
COVID-19 research risks ignoring important host genes due to pre-established research patterns.由于预先设定的研究模式，COVID-19 研究可能会忽略重要的宿主基因。
Elife. 2020 Nov 24;9:e61981. doi: 10.7554/eLife.61981.