C反应蛋白、纤维蛋白原、白细胞介素-6及巨噬细胞集落刺激因子在严重不稳定型心绞痛中的预后价值

Prognostic value of C-reactive protein, fibrinogen, interleukin-6, and macrophage colony stimulating factor in severe unstable angina.

作者信息

Rallidis Loukianos S, Zolindaki Maria G, Manioudaki Helen S, Laoutaris Nikolaos P, Velissaridou Aggeliki H, Papasteriadis Evangelos G

机构信息

Department of Cardiology, General Hospital of Nikea, Piraeus, Greece.

出版信息

Clin Cardiol. 2002 Nov;25(11):505-10. doi: 10.1002/clc.4960251106.

DOI:10.1002/clc.4960251106

PMID:12430780

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6654719/

Abstract

BACKGROUND

Inflammatory process plays an important role in the pathogenesis of acute coronary syndromes.

HYPOTHESIS

The study was undertaken to evaluate whether admission levels of C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6). and macrophage colony stimulating factor (MCSF) can predict short-term prognosis in patients with unstable angina.

METHODS

C-reactive protein, fibrinogen, IL-6, and MCSF were measured on admission in 141 consecutive patients, aged 59 +/- 10 years, with unstable angina (Braunwald class IIIb). Patients were divided into two groups according to their in-hospital outcome: Group 1 comprised 77 patients with a complicated course (2 died, 15 developed nonfatal myocardial infarction, and 60 had recurrence of angina), and Group 2 comprised 64 patients with an uneventful course.

RESULTS

Admission median levels of CRP (8.8 vs. 3.1 mg/l, p = 0.0002). fibrinogen (392 vs. 340 mg/dl, p = 0.008), IL-6 (8.8 vs. 4.5 pg/ml, p = 0.03), and MCSF (434 vs. 307 pg/ml, p = 0.0001) were higher in Group I than in Group 2. The MCSF levels were an independent risk factor for in-hospital events, with an adjusted odds ratio for eventful in-hospital outcome of 3.3 (95% confidence interval 1-10.9, p = 0.04), and correlated with levels of IL-6 (r(s) = 0.52, p = 0.0001), CRP (r(s) = 0.43, p = 0.0001), and fibrinogen (r(s) = 0.25, p = 0.004).

CONCLUSIONS

These findings suggest that among the studied inflammatory indices only increased admission levels of MCSF are strongly and independently related with adverse short-term prognosis in patients with severe unstable angina.

摘要

背景

炎症过程在急性冠脉综合征的发病机制中起重要作用。

假说

本研究旨在评估C反应蛋白（CRP）、纤维蛋白原、白细胞介素-6（IL-6）和巨噬细胞集落刺激因子（MCSF）的入院水平是否能预测不稳定型心绞痛患者的短期预后。

方法

对141例年龄59±10岁的连续不稳定型心绞痛患者（Braunwald IIIb级）入院时测定CRP、纤维蛋白原、IL-6和MCSF。根据住院结局将患者分为两组：第1组包括77例病程复杂的患者（2例死亡，15例发生非致命性心肌梗死，60例心绞痛复发），第2组包括64例病程平稳的患者。

结果

第1组CRP（8.8对3.1mg/l，p = 0.0002）、纤维蛋白原（392对340mg/dl，p = 0.008）、IL-6（8.8对4.5pg/ml，p = 0.03）和MCSF（434对307pg/ml，p = 0.0001）的入院中位数水平高于第2组。MCSF水平是住院事件的独立危险因素，住院结局不良的调整优势比为3.3（95%置信区间1 - 10.9，p = 0.04），且与IL-6水平（r(s) = 0.52，p = 0.0001）、CRP水平（r(s) = 0.43，p = 0.0001）和纤维蛋白原水平（r(s) = 0.25，p = 0.004）相关。