Summerfield A Quentin, Marshall David H, Barton Garry R, Bloor Karen E
Medical Research Council Institute of Hearing Research, University Park, Nottingham, England.
Arch Otolaryngol Head Neck Surg. 2002 Nov;128(11):1255-62. doi: 10.1001/archotol.128.11.1255.
Unilateral cochlear implantation is a cost-effective intervention for profound bilateral hearing loss. There is worldwide interest in providing implants bilaterally.
To use modeling to estimate the cost of gaining a quality-adjusted life-year by providing implants to both ears of profoundly postlingually deafened adults.
Economic scenario analysis relating the costs of providing implants to estimates of the gain in health-related quality of life (utility) from unilateral and bilateral implantation.
Fourteen hospitals in the United Kingdom National Health Service and 1 Medical Research Council research unit.
Normal-hearing adult volunteers with knowledge of implantation (n = 70). Adults undergoing unilateral implantation who either did not benefit from acoustic hearing aids preoperatively (type 1, n = 87) or benefited marginally (type 2, n = 115).
Changes in utility from unilateral and bilateral implantation estimated with the time trade-off technique (volunteers) and from unilateral implantation measured with the Mark II Health Utilities Index (patients); costs of providing implants and sustaining patients who have undergone implantation (health care perspective).
Gains in utility from unilateral implantation estimated by volunteers did not differ significantly from gains recorded by patients, giving credibility to the volunteers' estimate of the gain from bilateral compared with unilateral implantation. Cost-utility ratios, in pounds sterling per quality-adjusted life-year, based on volunteers' estimates, were pound 16,774 (type 1: unilateral implantation vs no intervention), pound 27,401 (type 2: unilateral implantation vs management with hearing aids), pound 61,734 (simultaneous bilateral implantation vs unilateral implantation), and pound 68,916 (provision of an additional implant vs no additional intervention).
More quality of life is likely to be gained per unit of expenditure on unilateral implantation than bilateral implantation.
单侧人工耳蜗植入是治疗重度双侧听力损失的一种具有成本效益的干预措施。全球都对双侧植入人工耳蜗感兴趣。
通过建模来估计为极重度语后聋成年人双耳植入人工耳蜗获得一个质量调整生命年的成本。
经济情景分析,将人工耳蜗植入成本与单侧和双侧植入后健康相关生活质量(效用)的改善估计值相关联。
英国国民医疗服务体系的14家医院和1个医学研究理事会研究单位。
了解植入情况的听力正常成年志愿者(n = 70)。术前未从助听器中获益的接受单侧植入的成年人(1型,n = 87)或获益甚微的成年人(2型,n = 115)。
用时间权衡技术(志愿者)估计单侧和双侧植入后的效用变化,用Mark II健康效用指数(患者)测量单侧植入后的效用变化;人工耳蜗植入成本以及维持植入患者的成本(医疗保健视角)。
志愿者估计的单侧植入效用增益与患者记录的效用增益无显著差异,这使得志愿者对双侧植入与单侧植入效用增益的估计具有可信度。基于志愿者估计值,每质量调整生命年的成本效用比分别为16,774英镑(1型:单侧植入与无干预相比)、27,401英镑(2型:单侧植入与使用助听器管理相比)、61,734英镑(同时双侧植入与单侧植入相比)和68,916英镑(额外植入与无额外干预相比)。
单侧植入每单位支出可能比双侧植入获得更多的生活质量。