何首乌中二苯乙烯苷的自由基清除作用。
The radical scavenging effects of stilbene glucosides from Polygonum multiflorum.
作者信息
Ryu Geonseek, Ju Jeung Hoon, Park Yong Ju, Ryu Shi Yong, Choi Byoung Wook, Lee Bong Ho
机构信息
Regional Research Center and Department of Chemical Technology, Hanbat National University, Yusung-ku, Daejon, Korea.
出版信息
Arch Pharm Res. 2002 Oct;25(5):636-9. doi: 10.1007/BF02976935.
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 microM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 microM).
通过体外DPPH自由基清除活性评估，何首乌根提取物表现出显著的抗氧化活性。对该提取物进行生物测定导向的分离，得到一种芪类糖苷，（E）-2,3,5,4'-四羟基芪-2-O-β-D-吡喃葡萄糖苷（1），作为具有抗氧化特性的活性成分。化合物1表现出中等的DPPH自由基清除活性（IC50，40 microM），而相应的去葡萄糖基化芪2表现出更高的活性（IC50，0.38 microM）。
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