Ryu Geonseek, Ju Jeung Hoon, Park Yong Ju, Ryu Shi Yong, Choi Byoung Wook, Lee Bong Ho
Regional Research Center and Department of Chemical Technology, Hanbat National University, Yusung-ku, Daejon, Korea.
Arch Pharm Res. 2002 Oct;25(5):636-9. doi: 10.1007/BF02976935.
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 microM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 microM).
通过体外DPPH自由基清除活性评估，何首乌根提取物表现出显著的抗氧化活性。对该提取物进行生物测定导向的分离，得到一种芪类糖苷，（E）-2,3,5,4'-四羟基芪-2-O-β-D-吡喃葡萄糖苷（1），作为具有抗氧化特性的活性成分。化合物1表现出中等的DPPH自由基清除活性（IC50，40 microM），而相应的去葡萄糖基化芪2表现出更高的活性（IC50，0.38 microM）。
