Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science & Technology, Tianjin University , Tianjin 300072, People's Republic of China.
J Nat Prod. 2014 Feb 28;77(2):397-401. doi: 10.1021/np400720y. Epub 2014 Feb 5.
Four new stilbene derivatives, polygonumosides A-D (1-4), were isolated from the processed roots of Polygonum multiflorum. Their structures were elucidated by spectroscopic analysis, including 1D and 2D NMR and ECD. Polygonumosides A (1) and B (2), possessing an unprecedented tetracyclic skeleton, were assigned as 2S- and 2R-2-(4-hydroxyphenyl)-9,10,11-trihydroxy-2H-benzo[c]furo[2,3-f]chromen-7(3H)-one-4-O-β-d-glucopyranosides, respectively, while polygonumosides C (3) and D (4) were assigned as a pair of diastereomeric stilbene glucoside dimers.
从何首乌的加工根部分离得到四个新的二苯乙烯衍生物，即化合物 1-4，分别命名为 polygonumosides A-D。通过光谱分析，包括 1D 和 2D NMR 和 ECD，确定了它们的结构。化合物 1 和 2 具有前所未有的四环骨架，分别被鉴定为 2S-和 2R-2-(4-羟基苯基)-9,10,11-三羟基-2H-苯并[c]呋喃[2,3-f]色烯-7(3H)-酮-4-O-β-d-吡喃葡萄糖苷，而化合物 3 和 4 则被鉴定为一对非对映异构体二苯乙烯葡萄糖苷二聚体。
