You Young-Jae, Lee Im-Seon, Kim Yong, Bae Ki-Hwan, Ahn Byung-Zun
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Arch Pharm Res. 2002 Oct;25(5):640-2. doi: 10.1007/BF02976936.
The ethyl acetate fraction of Bupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compounds P1 and P2 completely inhibited the tube-like formation of HUVE cells at 30 microg/ml, below the cytotoxic concentration. But, they did not exhibit antitumor activity on BDF1 mice bearing Lewis lung carcinoma cells despite their antiangiogenic activity.
发现长梗柴胡的乙酸乙酯部位对人脐静脉内皮（HUVE）细胞的管状形成具有抑制作用。从该部位分离出的活性化合物被鉴定为乙酰柴胡毒素（P1）和柴胡毒素（P2）。化合物P1和P2在30微克/毫升时完全抑制HUVE细胞的管状形成，该浓度低于细胞毒性浓度。但是，尽管它们具有抗血管生成活性，但对携带Lewis肺癌细胞的BDF1小鼠未表现出抗肿瘤活性。
