You Young-Jae, Nam Nguyen-Hai, Kim Yong, Bae Ki-Hwan, Ahn Byung-Zun
College of Pharmacy, Chungnam National University, Taejon 305-764, Korea.
Phytother Res. 2003 Apr;17(4):341-4. doi: 10.1002/ptr.1140.
In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.
在从越南药用植物中寻找抗血管生成剂的过程中，发现木棉茎皮的甲醇提取物对人脐静脉内皮细胞（HUVEC）的体外管形成具有显著的抗血管生成活性。对该提取物进行生物活性导向的分离和纯化，得到羽扇豆醇作为活性成分。羽扇豆醇在50和30μg/mL时对HUVEC管形成表现出显著的抑制活性，而对SK-MEL-2、A549和B16-F10黑色素瘤等肿瘤细胞系的生长没有影响。
