McLellan Tom M, Ducharme Michel B, Canini Frédéric, Moroz Dianne, Bell Doug G, Baranski Joseph V, Gil Valerie, Buguet Alain, Radomski Manny W
Defence and Civil Institute of Environmental Medicine, Environmental and Applied Ergonomics Section, Toronto, ON, Canada.
Aviat Space Environ Med. 2002 Nov;73(11):1079-88.
Previous studies have revealed that modafinil elevates resting core temperature during periods of sustained wakefulness. The purpose of this study was to examine the effects of modafinil on core temperature during rest and exercise throughout 40 h of sustained wakefulness in a warm environment.
Ten males performed a drug session (three 100 mg doses per day) and a placebo session that involved a control day, 40 h of sustained wakefulness, and a recovery sleep. For 38 h of the sustained wakefulness, subjects were exposed to 30 degrees C with 50% relative humidity. During the afternoon of both days of wakefulness and during the early morning of the second day, subjects performed 2 h of exercise at 60% VO2max while exposed to the warm environment.
The data revealed that rectal temperature (Tre) was elevated at rest 0.15-0.2 degrees C following modafinil ingestion throughout the period of sustained wakefulness. This increase in body temperature at rest was due to an increase in heat production during the first day of wakefulness followed by a lower evaporative heat loss during the second day. During exercise, an inconsistent effect of the drug on Tre was observed throughout the 38-h period. On the first afternoon, the impact of modafinil on Tre was no longer evident after 20 min of exercise. In contrast, during the early morning and afternoon of the second day, the effects of the drug on Tre at rest remained during exercise. For seven subjects who had Tre data for 80 min during all exercise periods, Tre during the placebo session was 38.9, 38.4, and 38.7 degrees C after 80 min of exercise for periods one, two and three, respectively, whereas the corresponding values during the modafinil session were 38.8, 38.7, and 38.9 degrees C.
With a greater cumulative dose of the drug, Tre remained elevated throughout the exercise period to an extent similar to the increase observed under resting conditions when compared with the placebo condition.
先前的研究表明，莫达非尼在持续清醒期间会升高静息核心体温。本研究的目的是在温暖环境中持续清醒40小时的过程中，研究莫达非尼对休息和运动期间核心体温的影响。
10名男性进行了药物试验（每天服用三次100毫克剂量）和安慰剂试验，其中包括一个对照日、40小时的持续清醒和一次恢复性睡眠。在持续清醒的38小时内，受试者暴露在30摄氏度、相对湿度50%的环境中。在清醒两天的下午以及第二天清晨，受试者在暴露于温暖环境的同时，以60%的最大摄氧量进行2小时的运动。
数据显示，在整个持续清醒期间，服用莫达非尼后静息时直肠温度（Tre）升高了0.15 - 0.2摄氏度。静息时体温的升高是由于清醒第一天产热增加，随后第二天蒸发散热减少所致。在运动期间，在38小时内观察到药物对Tre的影响不一致。在第一天下午，运动20分钟后莫达非尼对Tre的影响不再明显。相比之下，在第二天清晨和下午，药物对静息时Tre的影响在运动期间仍然存在。对于在所有运动时段都有80分钟Tre数据的7名受试者，在安慰剂试验期间，运动80分钟后，第一、二、三个时段的Tre分别为38.9、38.4和38.7摄氏度，而在莫达非尼试验期间，相应的值分别为38.8、38.7和38.9摄氏度。
与安慰剂相比，随着药物累积剂量的增加，在整个运动期间Tre持续升高，升高程度与静息条件下观察到的增加程度相似。
