van Dam Rob M, Feskens Edith J M
Department of Chronic Diseases Epidemiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands.
Lancet. 2002 Nov 9;360(9344):1477-8. doi: 10.1016/S0140-6736(02)11436-X.
Coffee is a major source of caffeine, which has been shown to acutely reduce sensitivity to insulin, but also has potentially beneficial effects. We prospectively investigated the association between coffee consumption and risk of clinical type 2 diabetes in a population-based cohort of 17111 Dutch men and women aged 30-60 years. During 125774 person years of follow-up, 306 new cases of type 2 diabetes were reported. After adjustment for potential confounders, individuals who drank at least seven cups of coffee a day were 0.50 (95% CI 0.35-0.72, p=0.0002) times as likely as those who drank two cups or fewer a day to develop type 2 diabetes. Coffee consumption was associated with a substantially lower risk of clinical type 2 diabetes.
咖啡是咖啡因的主要来源，已证明其会急性降低对胰岛素的敏感性，但也有潜在的有益作用。我们前瞻性地研究了在一个基于人群的队列中，17111名年龄在30至60岁的荷兰男性和女性中，咖啡消费与临床2型糖尿病风险之间的关联。在125774人年的随访期间，报告了306例2型糖尿病新病例。在对潜在混杂因素进行调整后，每天饮用至少七杯咖啡的个体患2型糖尿病的可能性是每天饮用两杯或更少咖啡的个体的0.50倍（95%置信区间0.35 - 0.72，p = 0.0002）。咖啡消费与临床2型糖尿病的风险显著降低相关。
