一项关于男性和女性补充维生素E摄入量与患结肠癌风险的前瞻性研究。

A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men.

作者信息

Wu Kana, Willett Walter C, Chan June M, Fuchs Charles S, Colditz Graham A, Rimm Eric B, Giovannucci Edward L

机构信息

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1298-304.

PMID:12433706

Abstract

We conducted a prospective study on the association between supplemental vitamin E and colon cancer in 87,998 females from the Nurses' Health Study and 47, 344 males from the Health Professionals Follow-up Study. There was some suggestion that men with supplemental vitamin E intake of 300 IU/day or more may be at lower risk for colon cancer when compared with never users [multivariate relative risk (RR), 300-500 IU/day versus never users, 0.73 (95% confidence interval (CI), 0.52-1.03); >or=600 IU/day versus never users = 0.70 (95% CI = 0.38-1.29)], but CIs included 1. In women, there was no evidence for an inverse association between vitamin E supplementation and risk of colon cancer. Our findings do not provide consistent support for an inverse association between supplemental vitamin E and colon cancer risk. Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted.

摘要

我们对护士健康研究中的87998名女性和健康专业人员随访研究中的47344名男性进行了一项关于补充维生素E与结肠癌之间关联的前瞻性研究。有迹象表明，与从未服用者相比，每日补充维生素E 300国际单位或更多的男性患结肠癌的风险可能较低[多变量相对风险（RR），300 - 500国际单位/天与从未服用者相比，为0.73（95%置信区间（CI），0.52 - 1.03）；≥600国际单位/天与从未服用者相比 = 0.70（95% CI = 0.38 - 1.29）]，但置信区间包含1。在女性中，没有证据表明补充维生素E与结肠癌风险之间存在负相关。我们的研究结果并未为补充维生素E与结肠癌风险之间的负相关提供一致的支持。鉴于关于这种关联的流行病学数据匮乏，有必要对维生素E与结肠癌进行进一步研究。