Ascherio Alberto, Weisskopf Marc G, O'reilly Eilis J, Jacobs Eric J, McCullough Marjorie L, Calle Eugenia E, Cudkowicz Merit, Thun Michael J
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Building 2, Boston, MA 02115, USA.
Ann Neurol. 2005 Jan;57(1):104-10. doi: 10.1002/ana.20316.
Oxidative stress may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). We therefore examined prospectively whether individuals who regularly use supplements of the antioxidant vitamins E and C have a lower risk of ALS than nonusers. The study population comprised 957,740 individuals 30 years of age or older participating in the American Cancer Society's Cancer Prevention Study II. Information on vitamin use was collected at time of recruitment in 1982; participants then were followed up for ALS deaths from 1989 through 1998 via linkage with the National Death Index. During the follow-up, we documented 525 deaths from ALS. Regular use of vitamin E supplements was associated with a lower risk of dying of ALS. The age- and smoking-adjusted relative risk was 0.99 (95% confidence interval [CI], 0.69-1.41) among occasional users, 0.59 (95% CI, 0.36-0.96) in regular users for less than 10 years, and 0.38 (95% CI, 0.16-0.92) in regular users for 10 years or more as compared with nonusers of vitamin E (p for trend = 0.004). In contrast, no significant associations were found for use of vitamin C or multivitamins. These results suggest that vitamin E supplementation could have a role in ALS prevention.
氧化应激可能在肌萎缩侧索硬化症（ALS）的发病机制中起作用。因此，我们前瞻性地研究了经常补充抗氧化维生素E和C的个体患ALS的风险是否低于不补充者。研究人群包括957,740名30岁及以上参与美国癌症协会癌症预防研究II的个体。1982年招募时收集了维生素使用信息；然后通过与国家死亡指数联动，对参与者从1989年至1998年的ALS死亡情况进行随访。随访期间，我们记录了525例ALS死亡病例。经常补充维生素E与死于ALS的风险较低有关。与不使用维生素E的人相比，偶尔使用者的年龄和吸烟调整后的相对风险为0.99（95%置信区间[CI]，0.69 - 1.41），使用维生素E少于10年的经常使用者为0.59（95%CI，0.36 - 0.96），使用维生素E 10年或更长时间的经常使用者为0.38（95%CI，0.16 - 0.92）（趋势p值 = 0.004）。相比之下，未发现补充维生素C或复合维生素有显著关联。这些结果表明补充维生素E可能在ALS预防中发挥作用。
