Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO, USA.
Breast Cancer Res Treat. 2018 Jan;167(2):529-535. doi: 10.1007/s10549-017-4517-9. Epub 2017 Sep 26.
Consumption of alcoholic beverages during adolescence and early adulthood has been consistently associated with higher breast cancer risk. The influence of alcohol consumption early in life on mammographic breast density, a marker of breast cancer risk, is inconclusive. This study examined associations of alcohol consumption across the life course with premenopausal mammographic density.
The study population included 1211 premenopausal women in the Nurses' Health Study II without cancer, who recalled their alcohol consumption at age 15 through enrollment in 1989 (baseline), and had mammograms available. Recent alcohol consumption was updated over follow-up. Percent and absolute measures of mammographic density were quantified on digitized film mammograms. Generalized linear regression was used to assess associations.
There were no notable differences in any of the three density measures for alcohol consumption at any age (15-17, 18-22, 23-30, and 31-mammogram). Neither alcohol consumption before first pregnancy nor after first pregnancy was significantly associated with any of the three density measures.
Moderate alcohol consumption during different age intervals during adolescence and early adulthood was not associated with mammographic density in premenopausal women.
青春期和成年早期饮酒与更高的乳腺癌风险一直有关。饮酒对生命早期乳房密度（乳腺癌风险的标志物）的影响尚无定论。本研究调查了整个生命过程中饮酒与绝经前乳房 X 光密度的关联。
该研究人群包括 1211 名在护士健康研究 II 中没有癌症的绝经前妇女，她们在 1989 年（基线）入组时回忆了自己 15 岁时的饮酒情况，并可获得乳房 X 光片。在随访过程中更新了最近的饮酒情况。通过数字化胶片乳房 X 光对乳腺密度的百分比和绝对测量进行量化。使用广义线性回归来评估关联。
在任何年龄（15-17、18-22、23-30 和 31 次乳房 X 光）的任何一项密度测量中，饮酒都没有明显差异。首次怀孕前或首次怀孕后的饮酒与任何一种密度测量都没有显著关联。
青春期和成年早期不同年龄段的中度饮酒与绝经前妇女的乳房 X 光密度无关。
