Fitzpatrick Michael F, Driver Helen S, Chatha Neela, Voduc Nha, Girard Alison M
Department of Medicine, Queen's University, Kingston, Ontario, Canada K7L 3N6.
J Appl Physiol (1985). 2003 Mar;94(3):883-90. doi: 10.1152/japplphysiol.00658.2002. Epub 2002 Nov 1.
The oral and nasal contributions to inhaled ventilation were simultaneously quantified during sleep in 10 healthy subjects (5 men, 5 women) aged 43 +/- 5 yr, with normal nasal resistance (mean 2.0 +/- 0.3 cmH(2)O. l(-1). s(-1)) by use of a divided oral and nasal mask. Minute ventilation awake (5.9 +/- 0.3 l/min) was higher than that during sleep (5.2 +/- 0.3 l/min; P < 0.0001), but there was no significant difference in minute ventilation between different sleep stages (P = 0.44): stage 2 5.3 +/- 0.3, slow-wave 5.2 +/- 0.2, and rapid-eye-movement sleep 5.2 +/- 0.2 l/min. The oral fraction of inhaled ventilation during wakefulness (7.6 +/- 4%) was not significantly different from that during sleep (4.3 +/- 2%; mean difference 3.3%, 95% confidence interval -2.1-8.8%, P = 0.19), and no significant difference (P = 0.14) in oral fraction was observed between different sleep stages: stage two 5.1 +/- 2.8, slow-wave 4.2 +/- 1.8, rapid-eye-movement 3.1 +/- 1.7%. Thus the inhaled oral fraction in normal subjects is small and does not change significantly with sleep stage.
在10名年龄为43±5岁（5名男性，5名女性）、鼻阻力正常（平均2.0±0.3 cmH₂O·l⁻¹·s⁻¹）的健康受试者睡眠期间，使用分开的口鼻面罩同时对经口和经鼻吸入通气量进行了量化。清醒时的分钟通气量（5.9±0.3 l/min）高于睡眠时（5.2±0.3 l/min；P<0.0001），但不同睡眠阶段的分钟通气量无显著差异（P = 0.44）：第二阶段为5.3±0.3，慢波睡眠为5.2±0.2，快速眼动睡眠为5.2±0.2 l/min。清醒时经口吸入通气的比例（7.6±4%）与睡眠时（4.3±2%）无显著差异（平均差异3.3%，95%置信区间为-2.1-8.8%，P = 0.19），不同睡眠阶段的经口比例也无显著差异（P = 0.14）：第二阶段为5.1±2.8，慢波睡眠为4.2±1.8，快速眼动睡眠为3.1±1.7%。因此，正常受试者经口吸入的比例较小，且不会随睡眠阶段发生显著变化。
