Nevéus T, Bader G, Sillén U
Uppsala University Children's Hospital, Sweden.
Acta Paediatr. 2002;91(10):1121-5. doi: 10.1080/080352502760311647.
To detect effects of desmopressin on sleep in enuretic children and to look for polysomnographical differences between responders and non-responders to desmopressin treatment.
Twenty-one children with primary nocturnal enuresis were examined polysomnographically before treatment. All but one of the children then received treatment with desmopressin in standard dosage, and the response was documented. Seven of the children underwent a second polysomnographic registration while on treatment.
The time interval (+/- 1 SD) between sleep onset and the enuretic episode was 92 +/- 67 min without medication and 372 +/- 157 min when desmopressin was given (p = 0.003). Standard polysomnographic variables were not affected by the drug. Ten children were desmopressin responders and 10 were non-responders. The total sleep time was 455 +/- 56 min in the former and 408 +/- 31 min in the latter group (p = 0.04). The responders spent 27.4 +/- 5.5% of their total sleep time in rapid eye movement sleep, compared with 18.2 +/- 6.5% in the non-responder group (p = 0.004).
Desmopressin has no major effects on sleep as such but does delay bladder emptying. Enuretic children responding to desmopressin treatment have more rapid eye movement sleep than therapy-resistant children.
检测去氨加压素对遗尿症儿童睡眠的影响，并寻找去氨加压素治疗反应者与无反应者之间的多导睡眠图差异。
21例原发性夜间遗尿症儿童在治疗前进行多导睡眠图检查。除1名儿童外，其他所有儿童均接受标准剂量的去氨加压素治疗，并记录治疗反应。其中7名儿童在治疗期间进行了第二次多导睡眠图记录。
未用药时，入睡至遗尿发作的时间间隔（±1标准差）为92±67分钟，给予去氨加压素后为372±157分钟（p = 0.003）。标准多导睡眠图变量不受该药物影响。10名儿童对去氨加压素治疗有反应，10名儿童无反应。前一组的总睡眠时间为455±56分钟，后一组为408±31分钟（p = 0.04）。反应者快速眼动睡眠占总睡眠时间的27.4±5.5%，无反应组为18.2±6.5%（p = 0.004）。
去氨加压素本身对睡眠无重大影响，但可延迟膀胱排空。对去氨加压素治疗有反应的遗尿症儿童比治疗抵抗性儿童有更多的快速眼动睡眠。
