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急性跟腱断裂的手术治疗与非手术治疗:期望值决策分析

Operative versus nonoperative management of acute Achilles tendon rupture: expected-value decision analysis.

作者信息

Kocher Mininder S, Bishop Julius, Marshall Ryan, Briggs Karen K, Hawkins Richard J

机构信息

Steadman-Hawkins Sports Medicine Foundation, Vail, Colorado, USA.

出版信息

Am J Sports Med. 2002 Nov-Dec;30(6):783-90. doi: 10.1177/03635465020300060501.

DOI:10.1177/03635465020300060501
PMID:12435641
Abstract

BACKGROUND

The optimal management strategy for acute Achilles tendon rupture is controversial.

PURPOSE

To determine the optimal management by using expected-value decision analysis.

STUDY DESIGN

Cross-sectional study.

METHODS

Outcome probabilities were determined from a systematic literature review, and patient-derived utility values were obtained from a visual analog scale questionnaire. A decision tree was constructed, and fold-back analysis was used to determine optimal treatment. Sensitivity analyses were used to determine the effect of varying outcome probabilities and utilities on decision-making.

RESULTS

Outcome probabilities (expressed as operative; nonoperative) were as follows: well (0.762; 0.846), rerupture (0.022; 0.121), major complication (0.030; 0.025), moderate complication (0.075; 0.003), and mild complication (0.111; 0.005). Outcome utility values were well operative (7.9), well nonoperative (7.0), rerupture (2.6), major complication (1.0), moderate complication (3.5), and mild complication (4.7). Fold-back analysis revealed operative treatment as the optimal management strategy (6.89 versus 6.30). Threshold values were determined for the probability of a moderate complication from operative treatment (0.21) and the utility of rerupture (6.8).

CONCLUSIONS

Operative management was the optimal strategy, given the outcome probabilities and patient utilities we studied. Nonoperative management was favored by increasing rates of operative complications; operative, by decreasing utility of rerupture. We advocate a model of doctor-patient shared decision-making in which both outcome probabilities and patient preferences are considered.

摘要

背景

急性跟腱断裂的最佳治疗策略存在争议。

目的

通过期望值决策分析确定最佳治疗方案。

研究设计

横断面研究。

方法

通过系统的文献综述确定结果概率,并通过视觉模拟量表问卷获得患者的效用值。构建决策树,并使用回溯分析来确定最佳治疗方案。敏感性分析用于确定不同结果概率和效用对决策的影响。

结果

结果概率(以手术;非手术表示)如下:良好(0.762;0.846),再断裂(0.022;0.121),严重并发症(0.030;0.025),中度并发症(0.075;0.003),轻度并发症(0.111;0.005)。结果效用值为手术良好(7.9),非手术良好(7.0),再断裂(2.6),严重并发症(1.0),中度并发症(3.5),轻度并发症(4.7)。回溯分析显示手术治疗是最佳管理策略(6.89对6.30)。确定了手术治疗中度并发症概率(0.21)和再断裂效用(6.8)的阈值。

结论

根据我们研究的结果概率和患者效用,手术治疗是最佳策略。手术并发症发生率增加有利于非手术治疗;再断裂效用降低则有利于手术治疗。我们提倡一种医患共同决策的模式,其中既要考虑结果概率,也要考虑患者偏好。

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