在意大利分离出的对红霉素耐药的化脓性链球菌咽部分离株。
Erythromycin-resistant pharyngeal isolates of Streptococcus pyogenes recovered in Italy.
作者信息
Dicuonzo Giordano, Fiscarelli Ersilia, Gherardi Giovanni, Lorino Giulia, Battistoni Fabrizio, Landi Simona, De Cesaris Marina, Petitti Tommasangelo, Beall Bernard
机构信息
Department of Laboratory Medicine. Hospital Infection Control Program, Università Campus Bio-Medico, Rome, Italy.
出版信息
Antimicrob Agents Chemother. 2002 Dec;46(12):3987-90. doi: 10.1128/AAC.46.12.3987-3990.2002.
Abstract
Three classes of macrolide resistance phenotypes and three different erythromycin resistance determinants were found among 127 erythromycin-resistant group A streptococcal (GAS) isolates recovered from 355 (35.8%) pediatric pharyngitis patients in Rome, Italy. According to emm and sof sequence typing results, erythromycin-resistant isolates comprised 11 different clonal types. Remarkably, 126 of the 127 macrolide-resistant isolates were serum opacity factor (sof) gene positive. These data suggest a strong association between macrolide resistance and the presence of sof among GAS isolates recovered from Italian pediatric pharyngitis patients.
摘要
在从意大利罗马355名（35.8%）小儿咽炎患者中分离出的127株耐红霉素A组链球菌（GAS）菌株中，发现了三类大环内酯耐药表型和三种不同的红霉素耐药决定因素。根据emm和sof序列分型结果，耐红霉素菌株包括11种不同的克隆类型。值得注意的是，127株大环内酯耐药菌株中有126株血清不透明因子（sof）基因呈阳性。这些数据表明，从意大利小儿咽炎患者中分离出的GAS菌株中，大环内酯耐药与sof的存在之间存在密切关联。
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