Oakley John C, Prager Joshua P
Northern Rockies Pain and Palliative Treatment Center, Billings, Montana 59101, USA.
Spine (Phila Pa 1976). 2002 Nov 15;27(22):2574-83. doi: 10.1097/00007632-200211150-00034.
A literature review and synthesis were performed.
To present the current understanding of the mechanisms of spinal cord stimulation in relation to the physiology of pain.
Spinal cord stimulation has been used for more than 30 years in the armamentarium of the interventional pain specialist to treat a variety of pain syndromes. Traditionally used for persisting leg pain after lumbar spinal surgery, it has been applied successfully in the treatment of angina pectoris, ischemic pain in the extremity, complex regional pain syndrome Types 1 and 2, and a variety of other pain states. This review presents the current status of what is known concerning how electrical stimulation of the spinal cord may achieve pain relief.
A literature review was conducted.
The literature supports the theory that the mechanism of spinal cord stimulation cannot be completely explained by one model. It is likely that multiple mechanisms operate sequentially or simultaneously.
Some clinical or experimental support can be found in the literature for 10 specific mechanisms or proposed mechanisms of spinal cord stimulation.
进行了文献综述与综合分析。
阐述目前对脊髓刺激与疼痛生理学相关机制的理解。
脊髓刺激已在介入疼痛专家的治疗手段中应用超过30年，用于治疗多种疼痛综合征。传统上用于治疗腰椎手术后持续的腿部疼痛，现已成功应用于治疗心绞痛、肢体缺血性疼痛、1型和2型复杂性区域疼痛综合征以及多种其他疼痛状态。本综述介绍了关于脊髓电刺激如何实现疼痛缓解的现有认知状况。
进行了文献综述。
文献支持这样一种理论，即脊髓刺激的机制无法用单一模型完全解释。很可能多种机制会依次或同时起作用。
文献中能找到一些针对脊髓刺激的10种特定机制或提出的机制的临床或实验支持。
