Kwaśny-Krochin B, Bobek M, Kontny E, Gluszko P, Biedroń R, Chain B M, Maśliński W, Marcinkiewicz J
Department of Rheumatology, Jagiellonian University School of Medicine, Cracow, Poland.
Amino Acids. 2002;23(4):419-26. doi: 10.1007/s00726-002-0207-x.
Taurine chloramine (TauCl), a product of neutrophil myeloperoxidase - halide system, formed by a reaction of taurine with HOCl, is known as an anti-microbial and anti-inflammatory long-lived oxidant. We previously reported that TauCl inhibits in vitro the production of proinflammatory cytokines (IL-6, IL-8) by RA synoviocytes. Therefore we performed this study to investigate the effect of TauCl treatment on the development of collagen-induced arthritis (CIA) in DBA1/J mice. Early administration of TauCl (after primary immunization) resulted in the delay of the onset of CIA, but had no effect on severity of arthritis. TauCl, given daily for 21 days after booster immunization, did not reduce the symptoms of arthritis in those mice, which already developed CIA, but significantly diminished incidence of the disease (55% vs. 90% of placebo mice). The mechanism of this effect is unknown. This is the first in vivo study suggesting that TauCl may be used for immune intervention in chronic inflammatory diseases.
牛磺酸氯胺（TauCl）是中性粒细胞髓过氧化物酶-卤化物系统的产物，由牛磺酸与次氯酸反应形成，是一种已知的具有抗菌和抗炎作用的长效氧化剂。我们之前报道过，TauCl在体外可抑制类风湿性关节炎滑膜细胞产生促炎细胞因子（IL-6、IL-8）。因此，我们开展了本研究，以探究TauCl处理对DBA1/J小鼠胶原诱导性关节炎（CIA）发展的影响。早期给予TauCl（初次免疫后）可导致CIA发病延迟，但对关节炎严重程度无影响。在加强免疫后连续21天每日给予TauCl，对那些已经患上CIA的小鼠的关节炎症状没有减轻作用，但可显著降低疾病发病率（与安慰剂组小鼠的90%相比为55%）。这种作用机制尚不清楚。这是第一项表明TauCl可用于慢性炎症性疾病免疫干预的体内研究。
