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4-氨基苯酚或4-二甲基氨基苯酚所致大鼠高铁血红蛋白血症及肾损害

Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol.

作者信息

Kiese M, Szinicz L, Thiel N, Weger N

出版信息

Arch Toxicol. 1975 Dec 18;34(4):337-40. doi: 10.1007/BF00353854.

DOI:10.1007/BF00353854
PMID:1243629
Abstract

4-Dimethylaminophenol hydrochloride (DMAP), 20mg/kg i.v., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400 mg/kg i.v., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.

摘要

静脉注射20毫克/千克的盐酸4-二甲基氨基酚（DMAP），可使大鼠体内高达50%的血红蛋白氧化为高铁血红蛋白，但不会导致肾脏损伤。静脉注射400毫克/千克的盐酸4-氨基酚，仅使25%的血红蛋白氧化，并产生大面积肾小管坏死。只有在高毒剂量下，例如半数致死量的两倍，DMAP才会产生肾小管坏死。

相似文献

1
Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol.4-氨基苯酚或4-二甲基氨基苯酚所致大鼠高铁血红蛋白血症及肾损害
Arch Toxicol. 1975 Dec 18;34(4):337-40. doi: 10.1007/BF00353854.
2
Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival.肌肉注射氰化物解毒剂对高铁血红蛋白形成和存活的有效性。
J Appl Toxicol. 1996 Nov-Dec;16(6):509-16. doi: 10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V.
3
[Antidotes in acute poisonings].[急性中毒的解毒剂]
Fortschr Med. 1977 Oct 27;95(40):2409-12.
4
Biotransformation of 4-dimethylaminophenol: reaction with glutathione, and some properties of the reaction products.4-二甲基氨基苯酚的生物转化：与谷胱甘肽的反应及反应产物的一些性质
Chem Biol Interact. 1976 Jul;14(1-2):165-78. doi: 10.1016/0009-2797(76)90034-x.
5
Kinetics of methaemoglobin production. (1). Kinetics of methaemoglobinaemia induced by the cyanide antidotes, p-aminopropiophenone, p-hydroxyaminopropiophenone or p-dimethylaminophenol after intravenous administration.高铁血红蛋白生成的动力学。(1). 静脉注射氰化物解毒剂对氨基苯丙酮、对羟基氨基苯丙酮或对二甲氨基苯酚后高铁血红蛋白血症的动力学。
Hum Toxicol. 1986 Sep;5(5):295-301. doi: 10.1177/096032718600500501.
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Pharm Res. 1988 Dec;5(12):749-52. doi: 10.1023/a:1015928432494.
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Site and mechanism of covalent binding of 4-dimethylaminophenol to human hemoglobin, and its implications to the functional properties.4-二甲基氨基苯酚与人血红蛋白的共价结合位点及机制及其对功能特性的影响。
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Circulation, respiration, and blood homeostasis in cyanide-poisoned dogs after treatment with 4-dimethylaminophenol or cobalt compounds.用4-二甲基氨基苯酚或钴化合物治疗后氰化物中毒犬的循环、呼吸和血液稳态
Arch Toxicol. 1979 Dec;43(2):121-33. doi: 10.1007/BF00333619.

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Arch Toxicol. 1993;67(9):613-21. doi: 10.1007/BF01974068.
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Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat.

本文引用的文献

1
[Oxidation of aniline to nitrosobenzene in dogs].[狗体内苯胺氧化为亚硝基苯的过程]
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Formation of ferrihaemoglobin with aminophenols in the human for the treatment of cyanide poisoning.人体中氨基酚与高铁血红蛋白的形成用于治疗氰化物中毒。
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Br Med J. 1969 Jan 18;1(5637):162-4. doi: 10.1136/bmj.1.5637.162.
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Comparative nephrotoxicity of aspirin and phenacetin derivatives.
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The role of N,N-dimethylaniline-N-oxide in the formation of hemiglobin following the absorption of N,N-dimethylaniline.N,N-二甲基苯胺-N-氧化物在吸收N,N-二甲基苯胺后形成高铁血红蛋白过程中的作用
Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;254(3):253-60. doi: 10.1007/BF00536223.
6
Nephrotoxicity and molecular structure.肾毒性与分子结构。
Xenobiotica. 1975 May;5(5):303-7. doi: 10.3109/00498257509052064.