循环免疫球蛋白E的意义。大鼠循环反应素抗体量与皮肤敏感性的相关性。
The significance of circulating IgE. Correlation of amount of circulating reaginic antibody with cutaneous sensitivity in the rat.
作者信息
Jarrett E E, Stewart D C
出版信息
Immunology. 1973 Jan;24(1):37-45.
In order to determine the relationship between the level of circulating reaginic (IgE) antibody and degree of cutaneous hypersensitivity, rats producing different titres of reaginic antibody were assessed for skin test reactivity by means of the active cutaneous anaphylaxis test. Skin reaction diameters of ovalbumin-sensitive rats were similar whether they were producing low or markedly elevated levels of ovalbumin reagins. In rats infected with , skin test reactivity to antigen was demonstrable before reagin became detectable in the circulation. It increased to maximum shortly after the appearance of circulating reagin, and thereafter showed no significant increase commensurate with the further rise in reagin titre. The results show that in the rat there is no direct quantitative relationship between the size of skin test reactions and the level of specific circulating reaginic antibody.
为了确定循环反应素（IgE）抗体水平与皮肤超敏反应程度之间的关系，通过主动皮肤过敏试验评估产生不同滴度反应素抗体的大鼠的皮肤试验反应性。卵清蛋白敏感大鼠的皮肤反应直径相似，无论它们产生的卵清蛋白反应素水平是低还是明显升高。在感染的大鼠中，在循环中可检测到反应素之前，对抗原的皮肤试验反应性就已显现。在循环反应素出现后不久，其反应性增加到最大值，此后，随着反应素滴度的进一步升高，未显示出显著增加。结果表明，在大鼠中，皮肤试验反应的大小与特异性循环反应素抗体水平之间没有直接的定量关系。
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