Chepurnov S A, Iniushkin A N
Lomonossov State University, 119899, Vorobievy Gory, Moscow, and State University, 443011, Samara, Pavlov St., 1, Russia.
Ross Fiziol Zh Im I M Sechenova. 1997 Apr;83(4):117-25.
Administration of substance P and kassinin into the solitary tract nucleus of anesthetized rats induced a dose-dependent increase in ventilation, tidal volume, inspiratory muscle activity, and a decrease in the mean blood pressure and heart rate. Microinjections of peptides caused a decrease in ventilatory response to hypoxia and an inhibition of the Breuer-Hering reflex. The data obtained suggest involvement of tachykinins in the respiratory and circulatory control via the solitary tract nucleus.
